Results 11 to 20 of about 110,116 (296)
Genome recoding by tRNA modifications [PDF]
Open Biology, 2016 RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. These modifications are particularly enriched in tRNAs where they can regulate not only global protein translation, but also protein translation at the ...
Francesca Tuorto, Frank Lyko
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m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +3 more
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Overview of tRNA Modifications in Chloroplasts [PDF]
Microorganisms, 2022 The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency.
Maxime Fages-Lartaud +1 more
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Extracurricular Functions of tRNA Modifications in Microorganisms [PDF]
Genes, 2020 Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality.
Ashley M. Edwards +2 more
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METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Clinical and Translational Medicine, 2021 Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood ...
Zhihang Chen +14 more
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Changes of the tRNA Modification Pattern during the Development of Dictyostelium discoideum
Non-Coding RNA, 2021 Dictyostelium discoideum is a social amoeba, which on starvation develops from a single-cell state to a multicellular fruiting body. This developmental process is accompanied by massive changes in gene expression, which also affect non-coding RNAs. Here,
Anne Hoffmann +5 more
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tRNA wobble modifications and protein homeostasis [PDF]
Translation, 2016 tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival.
Ranjan, N., Rodnina, M.
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Nature Communications, 2022 This paper develops a multiplex RNA-seq method that reports tRNA abundance, modification, charging, and fragmentation. Results show stress-induced regulation in translational elongation and association of modification and tRNA fragment biogenesis.
Christopher P. Watkins +4 more
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A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex [PDF]
, 2014 Elongator is a conserved, multi-protein complex discovered in Saccharomyces cerevisiae, loss of which confers a range of pleiotropic phenotypes. Elongator in higher eukaryotes is required for normal growth and development and a mutation in the largest ...
Amberg D.C. +5 more
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Bio-Protocol, 2019 Queuosine (Q) is a hypermodified base in the wobble anticodon position of tRNAs coding for the amino acids Tyr, His, Asn, and Asp. tRNA Q-modification is introduced by a queuine tRNA-ribosyltransferase (TGT) that replaces the guanine base at G34 at these
Zaneta Matuszek, Tao Pan
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