The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]
, 2007 The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T. +2 more
core +2 more sources
Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA
Microorganisms, 2018 To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes have been identified not only in thermophiles but also in mesophiles.
Hiroyuki Hori +6 more
doaj +1 more source
Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses [PDF]
, 2014 tRNA (tRNA) is a key molecule used for protein synthesis, with multiple points of stress-induced regulation that can include transcription, transcript processing, localization and ribonucleoside base modification.
Begley, Thomas J. +2 more
core +1 more source
Prediction of uridine modifications in tRNA sequences [PDF]
BMC Bioinformatics, 2014 In past number of methods have been developed for predicting post-translational modifications in proteins. In contrast, limited attempt has been made to understand post-transcriptional modifications. Recently it has been shown that tRNA modifications play direct role in the genome structure and codon usage.
Panwar, Bharat, Raghava, Gajendra PS
openaire +2 more sources
P348 tRNA modifications in Candida virulence
Medical Mycology, 2022 Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Candida albicans is a normal commensal of the gastrointestinal tract, but also an important opportunistic pathogen that can cause life-threatening infections. An important pathogenicity factor of C.
Böttcher, Bettina +2 more
openaire +1 more source
Regulatory Factors for tRNA Modifications in Extreme- Thermophilic Bacterium Thermus thermophilus
Frontiers in Genetics, 2019 Thermus thermophilus is an extreme-thermophilic bacterium that can grow at a wide range of temperatures (50–83°C). To enable T. thermophilus to grow at high temperatures, several biomolecules including tRNA and tRNA modification enzymes show extreme heat-
Hiroyuki Hori
doaj +1 more source
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]
, 2017 RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M +6 more
core +1 more source
7-Methylguanosine Modifications in tRNA [PDF]
International Journal of Molecular Sciences, 2018 More than 90 different modified nucleosides have been identified in tRNA. Among the tRNA modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria, eukaryotes, and a few archaea. In most cases, the m7G modification occurs at position 46 in the variable region and is a product of tRNA (m7G46) methyltransferase.
openaire +3 more sources
Impact of Pus1 Pseudouridine Synthase on Specific Decoding Events in Saccharomyces cerevisiae
Biomolecules, 2020 Pus1-dependent pseudouridylation occurs in many tRNAs and at multiple positions, yet the functional impact of this modification is incompletely understood.
Bahar Khonsari, Roland Klassen
doaj +1 more source
Posttranscriptional modification of tRNA in psychrophilic bacteria [PDF]
Journal of Bacteriology, 1997 Posttranscriptional modification in tRNA is known to play a multiplicity of functional roles, including maintenance of tertiary structure and cellular adaptation to environmental factors such as temperature. Nucleoside modification has been studied in unfractionated tRNA from three psychrophilic bacteria (ANT-300 and Vibrio sp.
J J, Dalluge +5 more
openaire +2 more sources