Results 21 to 30 of about 11,423 (138)

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

eLife, 2020
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A Fischer, Shafqat A Khan, Kyoung-mi Park, Eun-Ja Yoon, Xiaoyun Xing, Ramakrishna Kommagani, Ting Wang, Lilianna Solnica-Krezel, Thorold W Theunissen   +13 more
doaj   +1 more source

Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells

Reproductive Medicine and Biology, 2021
Purpose This study investigated the consistency between results of preimplantation genetic testing for aneuploidy performed on trophectoderm (TE) cells and remaining blastocyst cells.
Harunori Takahashi, Kazumasa Takahashi, Mayumi Goto, Takeo Hirakawa, Hisataka Hasegawa, Akihiro Shitara, Takuya Iwasawa, Kazue Togashi, Kenichi Makino, Hiromitsu Shirasawa, Hiroshi Miura, Wataru Sato, Yukiyo Kumazawa, Yukihiro Terada   +13 more
doaj   +1 more source

Morphometric assessment of blastocysts: relationship with the ongoing pregnancy rate

F&S Reports, 2023
Objective: To explore a morphometric grading system for blastocysts that is associated with ongoing pregnancy. Design: Cross-sectional study. Setting: None.
Hiroki Utsuno, Ph.D., Tomoko Ishimaru, B.S., Miho Matsumoto, B.S., Chiharu Sasamori, B.S., Hikaru Takahashi, M.L.T., Hiroko Kimura, M.D., Shintaro Kamijo, M.D., Mitsutoshi Yamada, M.D, Ph.D., Mamoru Tanaka, M.D., Ph.D., Toshio Hamatani, M.D., Ph.D.   +9 more
doaj   +1 more source

Effect of blastocyst quality on human sex ratio at birth in a single blastocyst frozen thawed embryo transfer cycle

Gynecological Endocrinology, 2023
Research question To determine whether blastocyst quality affects the sex ratio at birth through a single blastocyst frozen - thawed embryo transfer (SBFET) cycle.Design In this retrospective analysis, we examined 3,041 singleton infants born following ...
Yuling Mao, Ming Zeng, Ya-ming Meng, Chunyan Wang, Yanfen Luo, Yang Luo, Lei Li   +6 more
doaj   +1 more source

Comparison of cell lineage development and regulation during early embryonic development in cattle and mice

浙江大学学报. 农业与生命科学版, 2023
Low reproductive efficiency of high-yielding dairy cows is a worldwide challenge, among which the high mortality rate of early embryos is one of the main reasons.
WU Xiaotong, SHI Yan, LI Shuang, WANG Shaohua, ZHANG Kun   +4 more
doaj   +1 more source

Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells

Cell Reports, 2017
The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this ...
Ursula Nosi, Fredrik Lanner, Tsu Huang, Brian Cox   +3 more
doaj   +1 more source

Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection

iScience, 2023
Summary: Population-based genome-wide association studies (GWAS) normally require a large sample size, which can be labor intensive and costly. Recently, we reported a human induced pluripotent stem cell (hiPSC) array-based GWAS method, identifying ...
Liuliu Yang, Yuling Han, Ting Zhou, Lauretta A. Lacko, Mohsan Saeed, Christina Tan, Ron Danziger, Jiajun Zhu, Zeping Zhao, Clare Cahir, Alice Maria Giani, Yang Li, Xue Dong, Dorota Moroziewicz, Daniel Paull, Zhengming Chen, Aaron Zhong, Scott A. Noggle, Charles M. Rice, Qibin Qi, Todd Evans, Shuibing Chen   +21 more
doaj   +1 more source

Mitochondrial DNA copy number level in the culture medium of human embryos as a factor in predicting the onset and prolongation of pregnancy

RUDN Journal of Medicine
Relevance. A key factor influencing the effectiveness of assisted reproductive technology programmes is the quality of the embryo transferred into the uterine cavity.
Olga I. Lisitsyna, Nataliya P. Makarova, Aleksey M. Krasnyi, Alexey N. Ekimov, Andrey Yu. Romanov, Nataliya V. Dolgushina   +5 more
doaj   +1 more source

Effect of Different Volume of Microdrop Culture on B6D2F1 Mice Oogenesis

Journal of Animal Reproduction and Biotechnology, 2016
This study was conducted to evaluate the effects of different volume (100 μl vs. 2 ml) of microdrop culture on B6D2F1 mice oogenesis. In the present study, B6D2F1/CrljOri F1 mice were utilized in order to maximize oogenesis.
Chang-Seok Yoo, Kee Sang Park, Byoung Boo Seo   +2 more
doaj   +1 more source

Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan

Fertility & Reproduction, 2023
Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (
Chun-Kai Chen, Wei-Han Huang, Tiencheng Arthur Chang, Kuang-Han Chao, Wang-Fung Chiang, Hsin-Yi Yeh, Szu-Yu Shen   +6 more
doaj   +1 more source