Results 21 to 30 of about 15,306 (209)

Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

Epigenetics, 2020
Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development.
Panpan Zhao, Huanan Wang, Han Wang, Yanna Dang, Lei Luo, Shuang Li, Yan Shi, Lefeng Wang, Shaohua Wang, Jesse Mager, Kun Zhang   +10 more
doaj   +1 more source

Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos

Cell Reports, 2021
Summary: Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization,
Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, Marc Freichel   +15 more
doaj   +1 more source

Human trophectoderm cells are not yet committed [PDF]

Human Reproduction, 2012
Are human trophectoderm (TE) cells committed or still able to develop into inner cell mass (ICM) cells?Human full blastocyst TE cells still have the capacity to develop into ICM cells expressing the pluripotency marker NANOG, thus they are not yet committed.Human Day 5 full blastocyst TE cells express the pluripotency markers POU5F1, SOX2 and SALL4 as ...
De Paepe, Caroline, Cauffman, Greet, Verloes, An, Sterckx, Johan, Devroey, Paul, Tournaye, Herman, Liebaers, Ingeborg, Van De Velde, Hilde   +7 more
openaire   +4 more sources

Euploid Day-5 Blastocysts Versus Euploid Day-6 Blastocysts — Will the Reproductive Outcomes Differ? An Observational Study

Fertility & Reproduction, 2021
Background and objective: Day-5 blastocyst embryos are usually chosen for assisted reproductive therapy. We compared the reproductive outcomes of the euploid blastocysts developed on Day 5 versus Day 6.
Durga Gedela Rao, Krishna Chaitanya Mantravadi, Vijay Kumar Sharanappa   +2 more
doaj   +1 more source

The Human Early Maternal–Embryonic Interactome

Reproductive Medicine, 2023
Background: Single cell transcriptomics offers an avenue for predicting, with improved accuracy, the gene networks that are involved in the establishment of the first direct cell–cell interactions between the blastocyst and the maternal luminal ...
Adam Stevens, Taqua Khashkhusha, Megan Sharps, Terence Garner, Peter T. Ruane, John D. Aplin   +5 more
doaj   +1 more source

Preliminary assessment of aneuploidy rates between the polar, mid and mural trophectoderm [PDF]

, 2019
The objective of this study is to compare aneuploidy rates between three distinct areas of the human trophectoderm: mural, polar and a region in between these two locations termed the ‘mid’ trophectoderm. This is a cohort study on in vitro fertilization (
Katz, Seth L., Taylor, Tyl H., Johnson, Lauren, Patrick, Jennifer L., Stankewicz, Tiffany, Griffin, Darren K.   +5 more
core   +1 more source

Which is the safer method for trophectoderm biopsy in mouse blastocyst, mechanical or laser?

Clinical and Experimental Obstetrics & Gynecology, 2020
Introduction: This study was conducted to compare hatching rates after assisted hatching, re-expansion rates after trophectoderm biopsy, and survival rates after cryopreservation using different methods of assisted hatching and biopsy in mouse embryo ...
M.S. Jo, H.J. Lee, Y.J. Lee, S.C. Kim, J.K. Joo, K.S. Lee   +5 more
doaj   +1 more source

Tetraploid embryo aggregation produces high-quality blastocysts with an increased trophectoderm in pigs

Frontiers in Cell and Developmental Biology, 2023
Tetraploid complementation is an ideal method for demonstrating the differentiation potential of pluripotent stem cells. In this study, we selected the most efficient tetraploid production method for porcine embryos and investigated whether tetraploid ...
Joohyeong Lee, Lian Cai, Lian Cai, Lian Cai, Mirae Kim, Mirae Kim, Hyerin Choi, Hyerin Choi, Dongjin Oh, Dongjin Oh, Ali Jawad, Ali Jawad, Eunsong Lee, Sang-Hwan Hyun, Sang-Hwan Hyun, Sang-Hwan Hyun   +15 more
doaj   +1 more source

Preimplantation Genetic Testing for Families at Risk of Haemophilia: Ten-Year Single-Centre Experience. [PDF]

Haemophilia
ABSTRACT Introduction Preimplantation genetic testing for monogenic diseases (PGT‐M) is a reproductive option for couples at high risk of transmitting inherited disorders. We report a ten‐year single‐centre PGT‐M experience in families at risk of hemophilia.
Mortarino M, Garagiola I, Nicotra V, Riccaboni A, Guarneri C, Somigliana E, Peyvandi F.   +6 more
europepmc   +2 more sources

Derivation of Mouse Dome-Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts. [PDF]

Cell Prolif
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Liu M, Ren S, Xia X, Lu G, Yang H, Zheng Y, Zhao J, Zhao XY, Wang M.   +8 more
europepmc   +2 more sources