Results 31 to 40 of about 22,216 (269)

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities [PDF]

, 2014
STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization ...
Leary, C., Leary, Christine, Leese, H. J., Leese, Henry J., Sturmey, R. G., Sturmey, Roger G.   +5 more
core   +1 more source

Transitions in cell potency during early mouse development are driven by Notch

eLife, 2019
The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types.
Sergio Menchero, Isabel Rollan, Antonio Lopez-Izquierdo, Maria Jose Andreu, Julio Sainz de Aja, Minjung Kang, Javier Adan, Rui Benedito, Teresa Rayon, Anna-Katerina Hadjantonakis, Miguel Manzanares   +10 more
doaj   +1 more source

BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo

Biology Open, 2021
Human embryonic stem cells (hESCs) possess an immense potential to generate clinically relevant cell types and unveil mechanisms underlying early human development.
Sapna Chhabra, Aryeh Warmflash
doaj   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

A developmental insurance policy

eLife, 2017
Why does a totipotent state linger within the inner cell mass of mouse embryos?
Nestor Saiz, Anna-Katerina Hadjantonakis
doaj   +1 more source

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

eLife, 2020
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A Fischer, Shafqat A Khan, Kyoung-mi Park, Eun-Ja Yoon, Xiaoyun Xing, Ramakrishna Kommagani, Ting Wang, Lilianna Solnica-Krezel, Thorold W Theunissen   +13 more
doaj   +1 more source

Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells

Reproductive Medicine and Biology, 2021
Purpose This study investigated the consistency between results of preimplantation genetic testing for aneuploidy performed on trophectoderm (TE) cells and remaining blastocyst cells.
Harunori Takahashi, Kazumasa Takahashi, Mayumi Goto, Takeo Hirakawa, Hisataka Hasegawa, Akihiro Shitara, Takuya Iwasawa, Kazue Togashi, Kenichi Makino, Hiromitsu Shirasawa, Hiroshi Miura, Wataru Sato, Yukiyo Kumazawa, Yukihiro Terada   +13 more
doaj   +1 more source

Morphometric assessment of blastocysts: relationship with the ongoing pregnancy rate

F&S Reports, 2023
Objective: To explore a morphometric grading system for blastocysts that is associated with ongoing pregnancy. Design: Cross-sectional study. Setting: None.
Hiroki Utsuno, Ph.D., Tomoko Ishimaru, B.S., Miho Matsumoto, B.S., Chiharu Sasamori, B.S., Hikaru Takahashi, M.L.T., Hiroko Kimura, M.D., Shintaro Kamijo, M.D., Mitsutoshi Yamada, M.D, Ph.D., Mamoru Tanaka, M.D., Ph.D., Toshio Hamatani, M.D., Ph.D.   +9 more
doaj   +1 more source

Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation [PDF]

, 2017
In cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast
Berg, D, Maclean, P, Pfeffer, P, Smith, C   +3 more
core   +2 more sources

Effect of blastocyst quality on human sex ratio at birth in a single blastocyst frozen thawed embryo transfer cycle

Gynecological Endocrinology, 2023
Research question To determine whether blastocyst quality affects the sex ratio at birth through a single blastocyst frozen - thawed embryo transfer (SBFET) cycle.Design In this retrospective analysis, we examined 3,041 singleton infants born following ...
Yuling Mao, Ming Zeng, Ya-ming Meng, Chunyan Wang, Yanfen Luo, Yang Luo, Lei Li   +6 more
doaj   +1 more source