Results 51 to 60 of about 15,306 (209)
Advanced Science, EarlyView.NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu +10 more
wiley +1 more source
Trophectoderm Biopsy: Present State of the Art
GenesTrophectoderm (TE) biopsy is at present the most widely used procedure for preimplantation genetic testing (PGT). At the blastocyst stage, more TE cells (five to seven) can be obtained for genetic analysis. While removing TE cells and not touching the inner cell mass (ICM), the procedure is less invasive.
Anick De Vos, Neelke De Munck
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eLife, 2017 The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determined by position-dependent Hippo signaling. However, the window of responsiveness to Hippo signaling, the exact timing of lineage commitment and the
Eszter Posfai +7 more
doaj +1 more source
Fertility & Reproduction, 2023 Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (
Chun-Kai Chen +6 more
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Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Perceptions of trophectoderm as a sentinel for embryo selection [PDF]
Journal of Assisted Reproduction and Genetics, 2014 The archives of mammalian embryology are punctuated by landmark studies covering a rich tradition of technological bravado that spans 75 years. The most primordial perceptions of preimplantation embryo morphology were recorded at the Carnegie Institute for Embryology in Baltimore by the likes of Corner, Streeter, Hauser, Hartmann and others in the ...
openaire +2 more sources
Nature Communications, 2023 During preimplantation development, contractile forces generated at the apical cortex segregate cells into inner and outer positions of the embryo, establishing the inner cell mass (ICM) and trophectoderm.
Robin M. Skory +11 more
doaj +1 more source
ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research
Advanced Intelligent Systems, EarlyView.This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu +11 more
wiley +1 more source
Maternal and neonatal outcomes associated with trophectoderm biopsy
Fertility and Sterility, 2019 (Abstracted from Fertil Steril 2019;112:283–290) Despite a widespread increase in the use of preimplantation genetic testing (PGT), there remains inconclusive examination of maternal and neonatal outcomes after pregnancy achieved through in vitro fertilization (IVF) with PGT.
Wendy Y. Zhang +5 more
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C/EBPα instructs trophectoderm and pluripotency through the II6 pathway
, 2021 Continuous C/EBPa expression converts B cells into macrophages while its transient upregulation before the Yamanaka factors yields highly efficient iPSC reprogramming. C/EBP members regulate Il6 pathway genes and IL-6 signaling participates in macrophage
Plana Carmona, Marcos
core +1 more source