TEAD4 Regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during mouse blastocyst developmentTEAD4 Regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during mouse blastocyst development [PDF]
Open BiologyIn mammalian preimplantation embryos, distinct cell lineages occupy defined spatial niches. The outer trophectoderm (TE) forms an epithelial monolayer surrounding the inner cell mass (ICM) and blastocyst cavity. In mice, the Tead4 gene encodes a polarity-
Rebecca Collier +9 more
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Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction
STAR Protocols, 2021 Summary: Human trophoblasts arise from the morula as trophectoderm, which differentiates into cytotrophoblast, syncytiotrophoblast, and extravillous trophoblast after implantation.
Shingo Io +2 more
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Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
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Sox2 Is Essential for Formation of Trophectoderm in the Preimplantation Embryo
PLoS ONE, 2010 In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). Previously it was shown that Sox2-/- embryos die soon after implantation.
Keramari, Maria +6 more
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Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts.
PLoS ONE, 2010 During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2.
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Single-cell transcriptomic characterization of sheep conceptus elongation and implantation
Cell Reports, 2023 Summary: Bidirectional communication between the developing conceptus and endometrium is essential for pregnancy recognition and establishment in ruminants.
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Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.ABSTRACT Pregnancy loss (PL) remains a major limitation to reproductive efficiency in livestock, with a substantial proportion originating during early embryo development, particularly between blastocyst hatching and implantation. This developmental window encompasses complex processes of lineage differentiation and morphogenesis. Accumulating evidence
Alexia Siegmund‐Sabater +7 more
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The effects of aging on molecular modulators of human embryo implantation
iScience, 2021 Summary: Advancing age has a negative impact on female fertility. As implantation rates decline during the normal maternal life course, age-related, embryonic factors are altered and our inability to monitor these factors in an unbiased genome-wide ...
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, 2013 ICM/Trophectoderm differential cell count in blastocysts derived from fresh and freeze-dried lymphocytes.
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Recent Advances and Emerging Applications in Embryo Vitrification for Livestock
Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.ABSTRACT Vitrification has progressively supplanted conventional slow freezing as the method of choice for embryo cryopreservation in both human medicine and animal production, particularly for in vitro‐produced embryos and for species or developmental stages highly sensitive to conventional freezing.
Cristina Cuello +6 more
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