Results 1 to 10 of about 45,137 (199)
Isolation of First-Trimester and Full-term Human Placental Hofbauer Cells
Bio-Protocol, 2021 The placenta is the crucial organ that regulates the health of both mother and fetus during pregnancy. The human placenta is composed of villous tree-like structures that embed into the maternal decidua.
Anna Appios, Jake Thomas, Naomi McGovern
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Nature Communications, 2023 The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic ...
Jake R. Thomas +10 more
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Veterinary Sciences, 2022 Fetal growth is reliant on placental formation and function, which, in turn, requires the energy produced by the mitochondria. Prior work has shown that both mother and fetus operate via the phosphoinositol 3-kinase (PI3K)-p110α signalling pathway to ...
Daniela Pereira-Carvalho +3 more
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Physiological Reports, 2022 Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina +2 more
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Placental secretome characterization identifies candidates for pregnancy complications
Communications Biology, 2021 Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate the
Tina Napso +10 more
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Cells, 2023 Adverse maternal environments such as small size, malnutrition, and metabolic conditions are known to influence fetal growth outcomes. Similarly, fetal growth and metabolic alterations may alter the intrauterine environment and affect all fetuses in ...
Esteban Salazar-Petres +3 more
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Biology Open, 2021 The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation.
Malwina Prater +9 more
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Menstrual flow as a non-invasive source of endometrial organoids
Communications Biology, 2021 Tereza Cindrova-Davies et al. present a method for deriving endometrial organoids using menstrual flow collected from women. The approach shows promise as a personalised and non-invasive way to investigate gynaecological conditions such as endometriosis ...
Tereza Cindrova-Davies +6 more
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REPRODUCTION, 2012 This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene ...
Peter L, Pfeffer, David J, Pearton
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How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?
Frontiers in Immunology, 2021 Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to the ...
Oisín Huhn +10 more
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