Results 1 to 10 of about 87,349 (342)

Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells [PDF]

Cell Regeneration
The placenta plays a pivotal role in human pregnancy, yet research into placental development has been hindered by limited access to early-stage embryos and ethical constraints.
Qifan Jiang, Ping Liu, Chunlin Chen
doaj   +2 more sources

Mechanism of miR-20b-5p targeting HIF-1α in regulating trophoblast function in recurrent spontaneous abortion [PDF]

European Journal of Medical Research
Objective Recurrent spontaneous abortion (RSA) is a major pregnancy complication with unclear pathogenesis. This study aims to investigate the role of miR-20b-5p and its downstream target HIF-1α in trophoblast function and RSA pathogenesis.
Yihong Guo, Qiaoxian Wu, Lujing Chen, Yanyu Lai, Aizhen Fu   +4 more
doaj   +2 more sources

Spatial multiomics map of trophoblast development in early pregnancy

Nature, 2023
A multiomics single-cell atlas of the human maternal–fetal interface including the myometrium, combining spatial transcriptomics data with chromatin accessibility, provides a comprehensive analysis of cell states as placental cells infiltrate the uterus ...
A. Arutyunyan, Kenny Roberts, K. Troulé, Frederick C. K. Wong, M. Sheridan, Ilia Kats, L. Garcia-Alonso, B. Velten, R. Hoo, Elias R. Ruiz-Morales, Carmen Sancho-Serra, J. Shilts, Louis-François Handfield, Luca Marconato, E. Tuck, L. Gardner, C. Mazzeo, Qian Li, I. Kelava, G. J. Wright, E. Prigmore, Sarah A. Teichmann, O. Bayraktar, A. Moffett, O. Stegle, M. Turco, R. Vento-Tormo   +26 more
semanticscholar   +1 more source

Isolation of First-Trimester and Full-term Human Placental Hofbauer Cells

Bio-Protocol, 2021
The placenta is the crucial organ that regulates the health of both mother and fetus during pregnancy. The human placenta is composed of villous tree-like structures that embed into the maternal decidua.
Anna Appios, Jake Thomas, Naomi McGovern
doaj   +1 more source

Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice

Veterinary Sciences, 2022
Fetal growth is reliant on placental formation and function, which, in turn, requires the energy produced by the mitochondria. Prior work has shown that both mother and fetus operate via the phosphoinositol 3-kinase (PI3K)-p110α signalling pathway to ...
Daniela Pereira-Carvalho, Esteban Salazar-Petres, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri   +3 more
doaj   +1 more source

A comprehensive review of human trophoblast fusion models: recent developments and challenges

Cell Death Discovery, 2023
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast layer contributes to a successful pregnancy by secreting hormones necessary for pregnancy, transporting nutrients, mediating gas exchange, balancing immune ...
Xia Li, Zhuo-Hang Li, Ying-Xiong Wang, Taixiang Liu   +3 more
semanticscholar   +1 more source

Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

Nature Communications, 2023
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic ...
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern   +10 more
doaj   +1 more source

Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development

Physiological Reports, 2022
Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina, Graham J. Burton, Hong Wa Yung   +2 more
doaj   +1 more source

Placental secretome characterization identifies candidates for pregnancy complications

Communications Biology, 2021
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate the
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri   +10 more
doaj   +1 more source

Trophoblast development [PDF]

REPRODUCTION, 2012
This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene ...
Peter L, Pfeffer, David J, Pearton
openaire   +2 more sources