Results 11 to 20 of about 87,349 (342)

Early human trophoblast development: from morphology to function

Cellular and Molecular Life Sciences, 2022
Human pregnancy depends on the proper development of the embryo prior to implantation and the implantation of the embryo into the uterine wall. During the pre-implantation phase, formation of the morula is followed by internalization of blastomeres that ...
M. Gauster, G. Moser, S. Wernitznig, N. Kupper, B. Huppertz   +4 more
semanticscholar   +1 more source

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

Biology Open, 2021
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation.
Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies   +9 more
doaj   +1 more source

Local immune recognition of trophoblast in early human pregnancy: controversies and questions

Nature reviews. Immunology, 2022
Major human pregnancy disorders arise from the failure of placental trophoblast to access sufficient supplies of maternal oxygen and nutrients. Key to understanding this process are the interactions that occur early in pregnancy between trophoblast cells
A. Moffett, N. Shreeve
semanticscholar   +1 more source

Maternal and Intrauterine Influences on Feto-Placental Growth Are Accompanied by Sexually Dimorphic Changes in Placental Mitochondrial Respiration, and Metabolic Signalling Pathways

Cells, 2023
Adverse maternal environments such as small size, malnutrition, and metabolic conditions are known to influence fetal growth outcomes. Similarly, fetal growth and metabolic alterations may alter the intrauterine environment and affect all fetuses in ...
Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri   +3 more
doaj   +1 more source

WNT and NOTCH signaling in human trophoblast development and differentiation

Cellular and Molecular Life Sciences, 2022
Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful pregnancy outcome.
B. Dietrich, S. Haider, G. Meinhardt, J. Pollheimer, M. Knöfler   +4 more
semanticscholar   +1 more source

Menstrual flow as a non-invasive source of endometrial organoids

Communications Biology, 2021
Tereza Cindrova-Davies et al. present a method for deriving endometrial organoids using menstrual flow collected from women. The approach shows promise as a personalised and non-invasive way to investigate gynaecological conditions such as endometriosis ...
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J. P. Jones, Ashley Moffett, Graham J. Burton, Margherita Y. Turco   +6 more
doaj   +1 more source

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

bioRxiv, 2022
Infections at the maternal-fetal interface can directly harm the fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts and the maternal decidua must provide ...
Liheng Yang, E. C. Semmes, C. Ovies, Christina J. Megli, S. Permar, J. Gilner, C. Coyne   +6 more
semanticscholar   +1 more source

The multifaceted role of GCM1 during trophoblast differentiation in the human placenta

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Proper placental development is critical for pregnancy success. Placental maldevelopment is linked with serious pregnancy complications that jeopardize the health of both mother and child.
M. Jeyarajah, Gargi Jaju Bhattad, Rachel Kelly, K. Baines, Adam Jaremek, Fei Yang, Hiroaki Okae, T. Arima, V. Dumeaux, S. Renaud   +9 more
semanticscholar   +1 more source

Trophoblast Cell Subtypes and Dysfunction in the Placenta of Individuals with Preeclampsia Revealed by Single-Cell RNA Sequencing

Molecules and Cells, 2022
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining placental function. The heterogeneity of trophoblasts has been reported, but little is known about the trophoblast subtypes and distinctive functions during ...
Wenbo Zhou, Huiyan Wang, Yuqi Yang, F. Guo, Bin Yu, Zhaoliang Su   +5 more
semanticscholar   +1 more source

Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion

Theranostics, 2021
Rationale: Emerging evidence demonstrates that insufficient migration and invasion of trophoblasts play critical roles in the pathogenesis of recurrent spontaneous abortion (RSA). Cell-to-cell communication at the maternal-fetal interface is essential to
Jinli Ding, Yan Zhang, Xiaopeng Cai, Yi Zhang, Si-si Yan, Jiayu Wang, Sainan Zhang, Tailang Yin, Chaogang Yang, Jing Yang   +9 more
semanticscholar   +1 more source