Results 21 to 30 of about 109,495 (390)
Theranostics, 2021 Rationale: Emerging evidence demonstrates that insufficient migration and invasion of trophoblasts play critical roles in the pathogenesis of recurrent spontaneous abortion (RSA). Cell-to-cell communication at the maternal-fetal interface is essential to
Jinli Ding +9 more
semanticscholar +1 more source
Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]
, 2020 The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar +3 more
core +2 more sources
Characterization of primary models of human trophoblast
Development, 2021 Two recently developed models, trophoblast organoids and trophoblast stem cells (TSCs), are useful tools to further the understanding of human placental development. Both differentiate from villous cytotrophoblast (VCT) to either extravillous trophoblast
M. Sheridan +9 more
semanticscholar +1 more source
Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells
Science Advances, 2021 A simple and efficient strategy to generate human trophoblast stem cells is reported to aid investigations of early placentation. Human trophoblast stem cells (hTSCs) provide a valuable model to study placental development and function.
Yanxing Wei +19 more
semanticscholar +1 more source
Nature Communications, 2023 The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited.
Kaela M. Varberg +17 more
doaj +1 more source
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
eLife, 2020 Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
C. Dong +13 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Defective placentation, including impaired uterine spiral artery remodeling, leads to pregnancy disorders such as pregnancy loss, preeclampsia, intrauterine growth restriction, and preterm birth, all of which cause significant morbidity and ...
K. Varberg +14 more
semanticscholar +1 more source
Investigation of human trophoblast invasion in vitro.
Human Reproduction Update, 2020 BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction (FGR) and stillbirth.
Yassen Abbas +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 The immune tolerance microenvironment is crucial for the establishment and maintenance of pregnancy at the maternal-fetal interface. The maternal-fetal interface is a complex system containing various cells, including lymphocytes, decidual stromal cells,
Jinli Ding +5 more
semanticscholar +1 more source
Trophoblasts, invasion, and microRNA [PDF]
Frontiers in Genetics, 2013 MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous
Doridot, Ludivine +3 more
openaire +6 more sources