Results 21 to 30 of about 87,349 (342)

Regulation of human trophoblast gene expression by endogenous retroviruses

bioRxiv, 2022
Here the authors investigate the contribution of transposable elements to regulation of gene expression in human trophoblasts. Amongst other examples, they identify an LTR10A element with potential implications for preeclampsia.
J. Frost, Samuele M. Amante, Hiroaki Okae, E. Jones, B. Ashley, Rohan M. Lewis, J. Cleal, M. Caley, T. Arima, T. Maffucci, M. Branco   +10 more
semanticscholar   +1 more source

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

eLife, 2020
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
C. Dong, Mariana Beltcheva, P. Gontarz, Bo Zhang, Pooja Popli, Laura A. Fischer, S. Khan, Kyoung-mi Park, Eun-Ja Yoon, X. Xing, R. Kommagani, Ting Wang, L. Solnica-Krezel, T. Theunissen   +13 more
semanticscholar   +1 more source

Transcription factor networks in trophoblast development

Cellular and Molecular Life Sciences, 2022
The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles,
Henrieta Papuchova, P. Latos
semanticscholar   +1 more source

Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

iScience, 2023
Summary: Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and these ...
Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J.P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton, D. Stephen Charnock-Jones   +13 more
doaj   +1 more source

Investigation of human trophoblast invasion in vitro.

Human Reproduction Update, 2020
BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction (FGR) and stillbirth.
Yassen Abbas, M. Turco, G. Burton, A. Moffett   +3 more
semanticscholar   +1 more source

Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

Science Advances, 2021
A simple and efficient strategy to generate human trophoblast stem cells is reported to aid investigations of early placentation. Human trophoblast stem cells (hTSCs) provide a valuable model to study placental development and function.
Yanxing Wei, Tianyu Wang, Lishi Ma, Yanqi Zhang, Yuan Zhao, Kathryn Lye, Lu Xiao, Chunlin Chen, Zhijian Wang, Yanlin Ma, Xiaohua Zhou, F. Sun, Weili Li, C. Dunk, Siliang Li, A. Nagy, Yanhong Yu, G. Pan, S. Lye, Yongli Shan   +19 more
semanticscholar   +1 more source

Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape

Nature Communications, 2023
The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited.
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg   +17 more
doaj   +1 more source

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Frontiers in Immunology, 2021
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to the ...
Oisín Huhn, Oisín Huhn, Xiaohui Zhao, Laura Esposito, Laura Esposito, Ashley Moffett, Ashley Moffett, Francesco Colucci, Francesco Colucci, Andrew M. Sharkey, Andrew M. Sharkey   +10 more
doaj   +1 more source

A microphysiological model of human trophoblast invasion during implantation

Nature Communications, 2022
Successful establishment of pregnancy requires adhesion of an embryo to the endometrium and subsequent invasion into the maternal tissue. Abnormalities in this critical process of implantation and placentation lead to many pregnancy complications.
Ju Young Park, S. Mani, G. Clair, H. Olson, V. Paurus, C. Ansong, Cassidy Blundell, Rachel E. Young, J. Kanter, S. Gordon, Alex Y. Yi, M. Mainigi, D. Huh   +12 more
semanticscholar   +1 more source

Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]

PLoS ONE, 2014
The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis, Aron B Abera, Mushi Matjila, Robert P Millar, Arieh A Katz   +4 more
doaj   +1 more source