Results 31 to 40 of about 87,349 (342)

Characterization of primary models of human trophoblast

Development, 2021
Two recently developed models, trophoblast organoids and trophoblast stem cells (TSCs), are useful tools to further the understanding of human placental development. Both differentiate from villous cytotrophoblast (VCT) to either extravillous trophoblast
M. Sheridan, Xiaohui Zhao, R. Fernando, L. Gardner, V. Perez-Garcia, Qian Li, S. Marsh, R. Hamilton, A. Moffett, M. Turco   +9 more
semanticscholar   +1 more source

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BMC Biology, 2020
Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development.
Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu   +16 more
doaj   +1 more source

Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

Frontiers in Immunology, 2023
The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development.
Bai-Mei Zhuang, Bai-Mei Zhuang, Dan-Dan Cao, Xiao-Feng Liu, Li Wang, Xiao-Li Lin, Yong-Gang Duan, Cheuk-Lun Lee, Cheuk-Lun Lee, Philip C. N. Chiu, Philip C. N. Chiu, William S. B. Yeung, William S. B. Yeung, Yuan-Qing Yao, Yuan-Qing Yao, Yuan-Qing Yao   +15 more
doaj   +1 more source

Human placenta and trophoblast development: key molecular mechanisms and model systems

Cellular and Molecular Life Sciences, 2019
Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such
M. Knöfler, S. Haider, L. Saleh, J. Pollheimer, T. Gamage, J. James   +5 more
semanticscholar   +1 more source

BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation

Ecotoxicology and Environmental Safety, 2021
Human trophoblast cells play important role in embryo-fetal development. However, trophoblast cells are sensitive to environmental carcinogens. Recently, we have discovered that BPDE inhibits trophoblast cell migration, invasion and proliferation, and ...
Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, Huidong Zhang   +9 more
doaj   +1 more source

ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Defective placentation, including impaired uterine spiral artery remodeling, leads to pregnancy disorders such as pregnancy loss, preeclampsia, intrauterine growth restriction, and preterm birth, all of which cause significant morbidity and ...
K. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, K. Kozai, R. Choudhury, J. Aplin, R. Biswell, M. Gibson, Hiroaki Okae, T. Arima, J. Vivian, E. Grundberg, M. Soares   +14 more
semanticscholar   +1 more source

Extracellular Vesicles of Porphyromonas gingivalis Disrupt Trophoblast Cell Interaction with Vascular and Immune Cells in an In Vitro Model of Early Placentation

Life, 2023
Extracellular vesicles released by the primary pathogen of periodontal disease Porphyromonas gingivalis (Pg), referred to as outer membrane vesicles (OMVs), have been associated with the pathogenesis of systemic diseases like cardiovascular disease ...
Brenda Lara, Matías Sassot, Guillermina Calo, Daniel Paparini, Laura Gliosca, Gabriela Chaufan, Iñaki Loureiro, Daiana Vota, Rosanna Ramhorst, Claudia Pérez Leirós, Vanesa Hauk   +10 more
doaj   +1 more source

Trophoblast organoids as a model for maternal-fetal interactions during human placentation

Nature, 2018
The placenta is the extraembryonic organ that supports the fetus during intrauterine life. Although placental dysfunction results in major disorders of pregnancy with immediate and lifelong consequences for the mother and child, our knowledge of the ...
M. Turco, L. Gardner, R. Kay, R. Hamilton, Malwina Prater, M. Hollinshead, A. McWhinnie, L. Esposito, R. Fernando, H. Skelton, F. Reimann, F. Gribble, A. Sharkey, S. Marsh, S. O’Rahilly, M. Hemberger, G. Burton, A. Moffett   +17 more
semanticscholar   +1 more source

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse Models

Frontiers in Endocrinology, 2018
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development.
Laura Woods, Laura Woods, Vicente Perez-Garcia, Vicente Perez-Garcia, Myriam Hemberger, Myriam Hemberger   +5 more
doaj   +1 more source

Capturing Human Trophoblast Development with Naïve Pluripotent Stem Cells In Vitro

bioRxiv, 2020
Trophoblast are extra-embryonic cells that are essential to maintain pregnancy. Human trophoblasts arise from the morula as trophectoderm (TE), which, after implantation, differentiates into cytotrophoblast (CT), syncytiotrophoblast (ST), and ...
Shingo Io, Mio Kabata, Yoshiki Iemura, Katsunori Semi, N. Morone, I. Okamoto, Tomonori Nakamura, Yoji Kojima, C. Iwatani, H. Tsuchiya, Belinda Kaswandy, E. Kondoh, M. Saitou, Takuya Yamamoto, M. Mandai, Yasuhiro Takashima   +15 more
semanticscholar   +1 more source