Results 1 to 10 of about 88,882 (294)
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C [PDF]
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac ...
Monica X. Li+8 more
doaj +2 more sources
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease [PDF]
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin ...
Vikram Shettigar+19 more
doaj +2 more sources
Cardiac Manifestations and Emerging Biomarkers in Multisystem Inflammatory Syndrome in Children (MIS-C): A Systematic Review and Meta-Analysis [PDF]
Background: Cardiac involvement is a key prognostic factor in multisystem inflammatory syndrome in children (MIS-C), a rare but serious inflammatory condition that typically occurs 2–6 weeks after SARS-CoV-2 infection and is characterized by fever ...
Diana-Andreea Ciortea+6 more
doaj +2 more sources
Case report: Increased troponin level in 125 children during COVID-19
IntroductionIncrease in cardiac biomarkers during Coronavirus disease 2019 (COVID-19) was frequent regardless of the presence of myocarditis and multisystem inflammatory syndrome in children (MIS-C).
Paola Di Filippo+4 more
doaj +1 more source
Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation
Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca2+ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately ...
J. M. Chalovich, L. Zhu, D. Johnson
doaj +1 more source
Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardiac troponin ...
Mohammed A. Talle+4 more
doaj +1 more source
X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin
The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling.
Sarita Limbu+4 more
doaj +1 more source
Real-time quantitative reverse transcription PCR (RT-qPCR) is a sensitive and broadly used technique of assessing gene activity. To obtain a reliable result, stably expressed reference genes are essential for normalization of transcripts in various ...
Natalia Śmietana+4 more
doaj +1 more source
Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud+13 more
doaj +1 more source
An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]
Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran+6 more
doaj +1 more source