Results 1 to 10 of about 166,646 (357)
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C [PDF]
Biochemistry and Biophysics Reports, 2018 The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac ...
Monica X. Li +8 more
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Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils [PDF]
Frontiers in Physiology, 2011 Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little +4 more
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Computational Exploration and Characterization of Potential Calcium Sensitizing Mutations in Cardiac Troponin C. [PDF]
J Chem Inf Model, 2022 Hantz ER, Lindert S.
europepmc +3 more sources
Acta Medica AlanyaAim: Parameters used to determine prognosis in community-acquired pneumonia (CAP) patients often have limited clinical value. This study aims to examine the efficacy of CRP, albumin, CRP/albumin ratio and troponin elevation in predicting 30-day mortality
Halil İbrahim Doru +3 more
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Case report: Increased troponin level in 125 children during COVID-19
Frontiers in Pediatrics, 2023 IntroductionIncrease in cardiac biomarkers during Coronavirus disease 2019 (COVID-19) was frequent regardless of the presence of myocarditis and multisystem inflammatory syndrome in children (MIS-C).
Paola Di Filippo +4 more
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Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation
Frontiers in Physiology, 2022 Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca2+ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately ...
J. M. Chalovich, L. Zhu, D. Johnson
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Diagnostics, 2023 Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardiac troponin ...
Mohammed A. Talle +4 more
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Animals, 2020 Real-time quantitative reverse transcription PCR (RT-qPCR) is a sensitive and broadly used technique of assessing gene activity. To obtain a reliable result, stably expressed reference genes are essential for normalization of transcripts in various ...
Natalia Śmietana +4 more
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X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin
Cells, 2021 The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling.
Sarita Limbu +4 more
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An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]
PLoS ONE, 2013 Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran +6 more
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