Results 1 to 10 of about 19,854,960 (401)
The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. [PDF]
J Biol Chem, 2019 Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined. Here, we evaluated the pathogenicity of a previously unreported sarcomeric gene variant identified in a pediatric patient with sporadic dilated cardiomyopathy, and ...
Johnston JR +13 more
europepmc +6 more sources
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C [PDF]
Biochemistry and Biophysics Reports, 2018 The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac ...
Monica X. Li +8 more
doaj +2 more sources
The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review [PDF]
BJA OpenBackground: This systematic review describes the prognostic value of postoperative cardiac high-sensitive troponin I and T as risk markers for major adverse cardiac events (MACE) after coronary artery bypass graft (CABG) surgery and their predictive ...
Maaike S.Y. Thio +7 more
doaj +2 more sources
The enthalpy titration of troponin C with calcium
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1978 Microcalorimetric titrations have been used to study the binding of Ca2+ to troponin C, the Ca-binding component of troponin. Troponin C was extracted from rabbit skeletal muscle and Ca2+ was added to Ca-free troponin C in the presence of 1 mM Mg2+ at pH 8.83 at 10 degrees C.
Kazuhiro Yamada
openaire +4 more sources
Case report: Increased troponin level in 125 children during COVID-19
Frontiers in Pediatrics, 2023 IntroductionIncrease in cardiac biomarkers during Coronavirus disease 2019 (COVID-19) was frequent regardless of the presence of myocarditis and multisystem inflammatory syndrome in children (MIS-C).
Paola Di Filippo +4 more
doaj +1 more source
Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation
Frontiers in Physiology, 2022 Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca2+ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately ...
J. M. Chalovich, L. Zhu, D. Johnson
doaj +1 more source
Diagnostics, 2023 Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardiac troponin ...
Mohammed A. Talle +4 more
doaj +1 more source
Animals, 2020 Real-time quantitative reverse transcription PCR (RT-qPCR) is a sensitive and broadly used technique of assessing gene activity. To obtain a reliable result, stably expressed reference genes are essential for normalization of transcripts in various ...
Natalia Śmietana +4 more
doaj +1 more source
X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin
Cells, 2021 The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling.
Sarita Limbu +4 more
doaj +1 more source
An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]
PLoS ONE, 2013 Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran +6 more
doaj +1 more source