Results 31 to 40 of about 88,882 (294)

A computational exploration of the interactions of the green tea polyphenol (-)-Epigallocatechin 3-Gallate with cardiac muscle troponin C.

open access: yesPLoS ONE, 2013
Thanks to its polyphenols and phytochemicals, green tea is believed to have a number of health benefits, including protecting from heart disease, but its mechanism of action at the molecular level is still not understood.
Dominic Botten   +3 more
doaj   +1 more source

Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

open access: yesScientific Reports, 2023
The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic and diastolic ...
Priyanka Parijat   +6 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

Troponin-I is not falsely elevated in asymptomatic dialysis patients

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2013
Dialysis patients with troponin-I levels above the cut-off value diagnostic for acute myocardial event (AME) are sometimes labeled as having "renal cause" of elevated troponin-I.
Magdi M Hussein   +4 more
doaj   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

open access: yesAdvanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García   +23 more
wiley   +1 more source

Computational Studies of Cardiac and Skeletal Troponin

open access: yesFrontiers in Molecular Biosciences, 2019
Troponin is a key regulatory protein in muscle contraction, consisting of three subunits troponin C (TnC), troponin I (TnI), and troponin T (TnT). Calcium association to TnC initiates contraction by causing a series of dynamic and conformational changes ...
Jacob D. Bowman, Steffen Lindert
doaj   +1 more source

Blood C‐peptide concentration as a proxy marker of cardiovascular disease: An observational cross‐sectional study

open access: yesHealth Science Reports, 2023
Background and Aims Cardiovascular diseases (CVDs) are among the leading causes of disability and early death in sub‐Saharan Africa. Most of the current blood tests for CVD diagnosis involve performing about three test profiles; often at additional cost ...
Laurinda Adusu‐Donkor   +8 more
doaj   +1 more source

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

open access: yesAdvanced Healthcare Materials, EarlyView.
Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti   +11 more
wiley   +1 more source

Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients

open access: yesImmunity, Inflammation and Disease, 2022
Background Abnormal inflammation coagulation biomarker levels of troponin, C‐reactive protein (CRP), and D‐dimer levels in serum have been demonstrated to be associated and involved in the disease progression of coronavirus disease 2019 (COVID‐19 ...
Ayad M. Ali   +5 more
doaj   +1 more source

Changes and clinical values in serum levels of cardiac troponin I, cystatin C and N-terminal B-type natriuretic propeptide in patients with type 4 cardiorenal syndrome

open access: yesLinchuang shenzangbing zazhi, 2023
Objective To explore the clinical values of serum levels of cardiac troponin I (cTnI), cystatin C (CysC) and N-terminal B-type natriuretic propeptide (NT-proBNP) in patients with type IV cardiorenal syndrome (CRS) and examine their correlations with ...
Huang-qing Li, Yun-feng Ouyang, Jun Yang
doaj   +1 more source

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