Journal of Biological Chemistry, 2012 Background: The rate-limiting step of cardiac muscle relaxation is not completely understood. Results: We were able to measure two proposed rate-limiting steps of relaxation in ventricular myofibrils.
Sean C. Little +5 more
semanticscholar +1 more source
PLoS Comput. Biol., 2012 Troponin C (TnC) is implicated in the initiation of myocyte contraction via binding of cytosolic and subsequent recognition of the Troponin I switch peptide.
P. Kekenes-Huskey +2 more
semanticscholar +1 more source
Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis [PDF]
, 2015 Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease.
Chen, Xu-Miao +6 more
core +4 more sources
Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity*
Journal of Biological Chemistry, 2012 Background: Improved myofilament Ca2+ sensitivity alleviates defects in thin filament bearing disease-causing mutations. Results: By engineering the cardiac muscle Ca2+ sensor troponin C, aberrant myofilament Ca2+ sensitivity can be corrected in vitro ...
B. Liu +4 more
semanticscholar +1 more source
Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]
, 2005 Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen +5 more
core +1 more source
The cardiac Ca-sensitive regulatory switch, a system in dynamic equilibrium [PDF]
, 2008 The Ca-sensitive regulatory switch of cardiac muscle is a paradigmatic example of protein assemblies that communicate ligand binding through allosteric change. The switch is a dimeric complex of troponin C (TnC), an allosteric sensor for Ca, and troponin I (TnI), an allosteric reporter.
arxiv +1 more source
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]
, 2014 Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core +2 more sources
Type 2 myocardial infarction: the chimaera of cardiology? [PDF]
, 2015 The term type 2 myocardial infarction first appeared as part of the universal definition of myocardial infarction. It was introduced to cover a group of patients who had elevation of cardiac troponin but did not meet the traditional criteria for acute ...
[No authors listed] +46 more
core +1 more source
Risk markers by sex for in-hospital mortality in patients with acute coronary syndrome: a machine learning approach [PDF]
arXiv, 2021 Background: Several studies have highlighted the importance of considering sex differences in the diagnosis and treatment of Acute Coronary Syndrome (ACS). However, the identification of sex-specific risk markers in ACS sub-populations has been scarcely studied.
arxiv
Structure of trans-resveratrol in complex with the cardiac regulatory protein troponin C.
Biochemistry, 2011 Cardiac troponin, a heterotrimeric protein complex that regulates heart contraction, represents an attractive target for the development of drugs for treating heart disease.
Sandra E. Pineda-Sanabria +2 more
semanticscholar +1 more source