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Focus on cardiac troponin complex: From gene expression to cardiomyopathy [PDF]

open access: diamondGenes and Diseases
The cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin ...
Rosetta Ragusa, Chiara Caselli
doaj   +3 more sources

Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. [PDF]

open access: yesPLoS ONE, 2014
Cardiac troponin (cTn) is the Ca(2+)-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+) signal received at cardiac troponin C (cTnC) is ...
Jayant James Jayasundar   +4 more
doaj   +2 more sources

Troponin Variants as Markers of Skeletal Muscle Health and Diseases

open access: yesFrontiers in Physiology, 2021
Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen   +2 more
doaj   +1 more source

An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]

open access: yesPLoS ONE, 2013
Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran   +6 more
doaj   +1 more source

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]

open access: yesPLoS ONE, 2012
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu   +4 more
doaj   +1 more source

Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. [PDF]

open access: yesPLoS ONE, 2014
Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect
Bin Liu   +3 more
doaj   +1 more source

Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation

open access: yesFrontiers in Physiology, 2022
Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca2+ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately ...
J. M. Chalovich, L. Zhu, D. Johnson
doaj   +1 more source

Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

open access: yesFrontiers in Physiology, 2022
Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud   +13 more
doaj   +1 more source

Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits

open access: yesFrontiers in Physiology, 2022
Striated muscle contraction and relaxation is regulated by Ca2+ at the myofilament level via conformational modulations of the troponin complex. To understand the structure–function relationship of troponin in normal muscle and in myopathies, it is ...
Monica Rasmussen   +2 more
doaj   +1 more source

Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

open access: yesScientific Reports, 2023
The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic and diastolic ...
Priyanka Parijat   +6 more
doaj   +1 more source

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