Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. [PDF]
PLoS ONE, 2014 Cardiac troponin (cTn) is the Ca(2+)-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+) signal received at cardiac troponin C (cTnC) is ...
Jayant James Jayasundar +4 more
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Intermolecular And Dynamic Investigation of The Mechanism of Action of Reldesemtiv on Fast Skeletal Muscle Troponin Complex Toward the Treatment of Impaired Muscle Function. [PDF]
Protein J, 2023 Muscle weakness as a secondary feature of attenuated neuronal input often leads to disability and sometimes death in patients with neurogenic neuromuscular diseases.
Issahaku AR +3 more
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Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex. [PDF]
Chem Biol Drug Des, 2016 Schlecht W, Li KL, Hu D, Dong W.
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Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics. [PDF]
Nat Commun, 2023 Protein complexes are highly dynamic entities that display substantial diversity in their assembly, post-translational modifications, and non-covalent interactions, allowing them to play critical roles in various biological processes.
Chapman EA +11 more
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Influence of Anticoagulants on the Dissociation of Cardiac Troponin Complex in Blood Samples. [PDF]
Int J Mol SciImmunodetection of cardiac isoforms of troponin I (cTnI) and troponin T (cTnT) in blood samples is widely used for the diagnosis of acute myocardial infarction.
Riabkova NS +8 more
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Desensitization of the Cardiac Troponin Complex by TnI Phosphorylation and Epigallocatechin-3-Gallate [PDF]
ACS OmegaHelene Tigro +5 more
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Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch. [PDF]
PLoS ONE, 2014 The interaction between myosin and actin in cardiac muscle, modulated by the calcium (Ca2+) sensor Troponin complex (Tn), is a complex process which is yet to be fully resolved at the molecular level. Our understanding of how the binding of Ca2+ triggers
Nicole M Cordina +7 more
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Focus on cardiac troponin complex: From gene expression to cardiomyopathy [PDF]
Genes and DiseasesThe cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin ...
Rosetta Ragusa, Chiara Caselli
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Frontiers in Cardiovascular Medicine, 2021 Background: The measurement of cardiac troponin I (cTnI) is widely used in the diagnosis of acute myocardial infarction (AMI). Although existing cTnI detection methods measure total cTnI, the significance of undegraded full-size-cTnI levels is still not ...
Biao Huang +13 more
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Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases [PDF]
Animal Cells and SystemsThe troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle.
Dongju Han +3 more
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