Results 41 to 50 of about 86,589 (350)

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]

, 2018
Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen, Arimoto, Balling, Bolignano, Cabassi, Dupont, Gaggin, Gravning, Grodin, Guisado Espartero, Haehling, Harrell, Jackson, Lassus, Lassus, Lok, Maisel, Maisel, McMurray, McMurray, Miller, Miller, Nagarajan, Park, Pascual-Figal, Pencina, Pencina, Pocock, Ponikowski, Rahimi, Rush, Shlipak, Swedberg, Tentzeris, Zamora   +34 more
core   +4 more sources

Crystal structure of troponin C in complex with troponin I fragment at 2.3-Å resolution [PDF]

Proceedings of the National Academy of Sciences, 1998
Troponin (Tn), the complex of three subunits (TnC, TnI, and TnT), plays a key role in Ca 2+ -dependent regulation of muscle contraction. To elucidate the interactions between the Tn subunits and the conformation of TnC in the Tn complex, we have determined the crystal structure of TnC (two Ca 2+
Kayo Maeda, Soichi Wakatsuki, Yuichiro Maéda, Dmitry G. Vassylyev, Soichi Takeda   +4 more
openaire   +3 more sources

High bleeding risk in patients undergoing percutaneous coronary intervention with drug-eluting stent implantation: ReCre8 subanalysis

American Heart Journal Plus, 2022
Objectives: In an all-comers cohort undergoing percutaneous coronary intervention (PCI), we aimed to assess prevalence of high bleeding risk (HBR) patients and impact of HBR and dual antiplatelet therapy (DAPT) on clinical events.
Nicole D. van Hemert, Pieter R. Stella, Rik Rozemeijer, Mèra Stein, Peter Frambach, Adriaan O. Kraaijeveld, Saskia Z. Rittersma, Timion A. Meijs, Geert E.H. Leenders, Pim van der Harst, Pierfrancesco Agostoni, Michiel Voskuil   +11 more
doaj   +1 more source

Crosstalk within Cardiac Troponin Complex with the R145W Mutation in Cardiac Troponin I [PDF]

Biophysical Journal, 2016
The cardiac troponin I (cTnI) inhibitory peptide (IPcTnI) and N-terminal domains (NtcTnI) both regulate the affinity of troponin C (cTnC) to Ca2+ being substrates for protein kinases -C (PKC; T143) and -A (PKA; S23/24), respectively. The R145W mutation localized next to the T143 site has been linked to the development of restrictive cardiomyopathy (RCM)
Alexey V. Dvornikov, Jodi L. Martin, Nikolai Smolin, Seth L. Robia, Pieter P. de Tombe   +4 more
openaire   +2 more sources

Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. [PDF]

PLoS ONE, 2013
The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on and off muscle contraction. In skeletal troponin binding of calcium to sites I and II of the TnC subunit results in a set of structural ...
Georgi Z Genchev, Tomoyoshi Kobayashi, Hui Lu   +2 more
doaj   +1 more source

Phosphorylation of troponin and the effects of interactions between the components of the complex [PDF]

Biochemical Journal, 1974
1. The troponin complex from skeletal muscle contains approximately 1 mol of phosphate/80000g of complex, covalently bound to the troponin T component. 2. On prolonged incubation of the troponin complex or troponin T with phosphorylase kinase the phosphate content of troponin T was increased to approx. 3mol/mol. 3. On prolonged incubation of troponin I
S. V. Perry, H. A. Cole
openaire   +4 more sources

The 99th percentile of reference population for cTnI and cTnT assay: Methodology, pathophysiology and clinical implications [PDF]

, 2017
According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit ...
Clerico, Aldo, Masotti, Silvia, Passino, Claudio, Plebani, Mario, Prontera, Concetta, Ripoli, Andrea, Zaninotto, Martina   +6 more
core   +1 more source

Modeling Human Cardiac Thin Filament Structures

Frontiers in Physiology, 2022
Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz, Elumalai Pavadai, William Lehman   +2 more
doaj   +1 more source

The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]

Biochemistry, 2002
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear, William T. Heller, Jill Trewhella, Natosha Finley, Ekram Abusamhadneh   +4 more
openaire   +3 more sources

Prognostically Significant Myocardial Injury in Patients Undergoing Transcatheter Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the optimal cutoff
Vikram Sharma, Tanujit Dey, Kesavan Sankaramangalam, Shehab A. R. Alansari, Louis Williams, Stephanie Mick, Amar Krishnaswamy, Lars G. Svensson, Samir Kapadia   +8 more
doaj   +1 more source