Results 51 to 60 of about 43,375 (307)

Establishment and Application of a Dual-Labeling Time-Resolved Fluorescence Immunoassay Method for Simultaneous Detection of the Troponin I-C Complex and Full-Size-Troponin I

Frontiers in Cardiovascular Medicine, 2021
Background: The measurement of cardiac troponin I (cTnI) is widely used in the diagnosis of acute myocardial infarction (AMI). Although existing cTnI detection methods measure total cTnI, the significance of undegraded full-size-cTnI levels is still not ...
Biao Huang, Jian Wu, Jian Wu, Hao Chen, Li Zhang, Xiumei Zhou, Qingqing Wu, Ting Li, Yigang Wang, Penguo Xia, Yaping Dai, Guoyin Kai, Pengfei Liu, Hao Pei   +13 more
doaj   +1 more source

Label‐Free, Sensitive, and Direct Detection of Cardiac Troponin Biomarkers Using Frequency‐Locked Microring Resonators

Advanced Sensor Research, EarlyView.
A deployable, chip‐integrated approach to the detection of heart attack biomarkers is demonstrated using silicon photonic microring resonators combined with microfluidics. By applying the Pound–Drever–Hall frequency locking technique, sensor signals are measured with improved signal‐to‐noise ratio, applying this to real‐time, selective readouts.
Evan Diamandikos, Tetsuya Shimogaki, Crispin Szydzik, Peter Thurgood, Luke H. Broadley, Sonya Palmer, Guanghui Ren, Thach G. Nguyen, Cesar S. Huertas, Arnan Mitchell   +9 more
wiley   +1 more source

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

Biochemistry and Biophysics Reports, 2018
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac ...
Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, Peter M. Hwang   +8 more
doaj  

Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment–Troponin C System

Molecules, 2015
Most of the current docking procedures are focused on fine conformational adjustments of assembled complexes and fail to reproduce large-scale protein motion. In this paper, we test a new modeling approach developed to address this problem.
Jacek Wabik, Mateusz Kurcinski, Andrzej Kolinski   +2 more
doaj   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients.

PLoS ONE, 2019
BACKGROUND:Electroconvulsive therapy (ECT) is an effective treatment method used in psychiatry; however, its cardiac safety has not been clearly demonstrated.
Michał Próchnicki, Grzegorz Rudzki, Michał Dzikowski, Andrzej Jaroszyński, Hanna Karakula-Juchnowicz   +4 more
doaj   +1 more source

THE ROLE OF OBESITY IN THE DEVELOPMENT OF INFLAMMATION AND PROGRESSION OF HEART FAILURE IN CORONAVIRUS DISEASE

Медична наука України, 2022
Relevance. Tissue plays a complex physiological role and may therefore progress to COVID-19 and heart failure. Objective is to evaluate the definition and myocardial biomarkers in a patient with viral disease in combination with obesity and heart ...
O.O. Samchuk, O.S. Kapustynska, E.Ya. Sklyarov E.Ya.   +2 more
doaj   +1 more source

Label‐Free Single‐Molecule Immunoassay

Advanced Science, EarlyView.
Label‐free single‐molecule immunoassay (LFSMiA) enables ultra‐sensitive and wide dynamic range protein detection in whole blood samples. LFSMiA features real‐time single‐molecule imaging by plasmonic scattering microscopy, background reduction by a 2‐step sandwich assay, minimizing matrix effect by dynamic tracking of single binding events, and ...
Xiaoyan Zhou, Chao Chen, Shuang Zhou, Guangzhong Ma, Mohammad Javad H. N. Chemerkouh, Christine L. H. Snozek, Eric H. Yang, Jiapei Jiang, Brandyn Braswell, Zijian Wan, Xinyu Zhou, Shaopeng Wang   +11 more
wiley   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. [PDF]

PLoS Computational Biology, 2012
Striated muscle contraction is a highly cooperative process initiated by Ca²⁺ binding to the troponin complex, which leads to tropomyosin movement and myosin cross-bridge (XB) formation along thin filaments. Experimental and computational studies suggest
Bertrand C W Tanner, Thomas L Daniel, Michael Regnier   +2 more
doaj   +1 more source