Results 101 to 110 of about 171,879 (297)

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

Frontiers in Pharmacology
IntroductionVoriconazole is widely used to prevent and treat invasive aspergillosis. However, its use is restricted by adverse effects, including acute liver injury (ALI).
Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang   +8 more
doaj   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Positively Charged Polymer‐Brush MOFs for Large‐Area, Pressure‐Resistant Gas Separation Membranes

Advanced Materials, EarlyView.
A universal POPA strategy enables positively charged polymer‐brush MOFs with self‐adaptive interfacial interlocking to resist aggregation under fast processing. This design ensures seamless dispersion within large‐area selective layers, achieving 1 m‐wide roll‐to‐roll fabrication of pressure‐resistant MMCMs with tunable CO2 separation performance ...
Yi Yang, Ye Yuan, Yuxiu Sun, Fei Shi, Chenyang Song, Weifan Wang, Qinghua Li, Menglong Sheng, Zhihua Qiao, Jingwei Hou, Anthony K. Cheetham, Zhi Wang   +11 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

A Comprehensive Review of Waste‐Derived Materials for Solar Still Performance Enhancement

Advanced Materials Interfaces, EarlyView.
ABSTRACT Solar desalination reduces energy use and produces freshwater sustainably, but its productivity is limited and cannot meet rising demand. Thus, solar desalination system improvements are sought to boost water productivity. Waste materials are abundantly available and burden the environment, making them low‐cost enhancers for solar desalination
A. S. Abdullah, Abanob Joseph, Wissam H. Alawee, Gamal B. Abdelaziz, Mohammed El Hadi Attia, Swellam W. Sharshir, Ahmed El‐Harairy   +6 more
wiley   +1 more source

Is it time to recommend AUC-based vancomycin therapeutic drug monitoring only? A cross-sectional survey in China

Frontiers in Pharmacology
BackgroundThe latest published therapeutic drug monitoring (TDM) guidelines for vancomycin recommend changing trough-based monitoring to area under the concentration-to-time curve (AUC)-based monitoring.
Jieqiong Liu, Jieqiong Liu, Xuan Zhang, Gang Liang, Jianping Zhu, Yi Yang, Ying Zheng, Yun Han, Yun Han, Yun Han, Lingyan Yu, Lingyan Yu, Yuhua Zhao, Zhenwei Yu, Zhenwei Yu   +14 more
doaj   +1 more source

Solar photochemical process engineering for production of fuels and chemicals [PDF]

The engineering costs and performance of a nominal 25,000 scmd (883,000 scfd) photochemical plant to produce dihydrogen from water were studied. Two systems were considered, one based on flat-plate collector/reactors and the other on linear parabolic ...
Biddle, J. R., Fujita, T., Peterson, D. B.   +2 more
core   +1 more source

Magnitude and Extent of Contaminated Sediment and Toxicity in Chesapeake Bay [PDF]

, 2007
INTRODUCTION: This report summarizes the results of NOAA's sediment toxicity, chemistry, and benthic community studies in the Chesapeake Bay estuary. As part of the National Status and Trends (NS&T) Program, NOAA has conducted studies to determine the
Hameedi, Jawed, Hartwell, S. Ian
core