Results 131 to 140 of about 52,480 (256)

Effect of traumatic brain injury on the trough concentration of linezolid in patients with hospital-acquired pneumonia. [PDF]

Sci Rep
Zhang Y, Tang L, Ma M, Zhuang Z, Xu J, Shi L, Zhang Q, Yu Y, Yu Z, Xu G.   +9 more
europepmc   +1 more source

Construction and Interpretation of Prediction Model of Teicoplanin Trough Concentration via Machine Learning. [PDF]

Front Med (Lausanne), 2022
Ma P, Liu R, Gu W, Dai Q, Gan Y, Cen J, Shang S, Liu F, Chen Y.   +8 more
europepmc   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Evaluation of everolimus pharmacokinetic monitoring based on trough concentration and area under the blood concentration time curve in kidney transplantation. [PDF]

BMC Nephrol
Fukae S, Kakuta Y, Matsumura S, Tanaka R, Kawamura M, Nakazawa S, Nonomura N.   +6 more
europepmc   +1 more source

Prediction for Plasma Trough Concentration and Optimal Dosing of Imatinib under Multiple Clinical Situations Using Physiologically Based Pharmacokinetic Modeling. [PDF]

ACS Omega, 2023
Gao D, Wang G, Wu H, Wu J, Zhao X.
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Nephrocast-V: A Deep Learning Model for the Prediction of Vancomycin Trough Concentration Using Electronic Health Record Data. [PDF]

Pharmacotherapy
Ghanbari G, Stevens C, Aronoff-Spencer E, Malhotra A, Nemati S, Yousif Z.   +5 more
europepmc   +1 more source

Trough Concentration Divided by Surface Area [PDF]

, 2020
openaire   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. [PDF]

World J Clin Cases
Guo T, Du LY, Liu MF, Zhou XJ, Chen XR.
europepmc   +1 more source