Variability of Tacrolimus Trough Concentration in Liver Transplant Patients: Which Role of Inflammation? [PDF]
Pharmaceutics, 2021 Tacrolimus presents high intra and inter-individual variability in its blood trough concentration (Cmin). Knowledge of the factors that are involved in tacrolimus Cmin variability is thus clinically important to prevent or limit it.
Anaelle Chavant +5 more
doaj +2 more sources
Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy [PDF]
Frontiers in Pharmacology, 2023 Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao +18 more
doaj +2 more sources
Predictors of target initial teicoplanin trough concentration attainment in patients with hematological malignancies: a retrospective cohort study [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground Teicoplanin (TEIC) is frequently used at Osaka Metropolitan University Hospital to treat infections caused by gram-positive cocci in patients with hematological malignancies.
Kazuki Deguchi +6 more
doaj +2 more sources
Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration [PDF]
Dose-ResponseObjective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood
Lin Wang +5 more
doaj +2 more sources
A real-world study of the optimal cut-off value for vancomycin trough concentration associated with outcomes in children infected with drug-resistant Gram-positive bacteria [PDF]
Frontiers in PediatricsBackgroundDue to a lack of studies on the relationship between vancomycin trough concentration and clinical outcomes in pediatric patients, there is insufficient evidence to provide a unified standard for vancomycin trough concentration for children ...
Yinghui Yan +6 more
doaj +2 more sources
Factors influencing vancomycin trough concentration in burn patients: a single center retrospective study [PDF]
Frontiers in PharmacologyObjectiveTo analyze factors influencing the vancomycin trough concentration in burn patients to provide a basis for the more rational use of vancomycin in these patients.Materials and methodsWe collected the clinical data of adult burn patients treated ...
Yan Shi +4 more
doaj +2 more sources
Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients [PDF]
Frontiers in Pharmacology, 2022 Inter- and intrapatient variability of tacrolimus exposure is a vital prognostic risk factor for the clinical outcome of liver transplantation. New factors or biomarkers characterizing tacrolimus disposition is essential for optimal dose prediction in ...
Huaijun Zhu +15 more
doaj +2 more sources
Tacrolimus Trough Concentration‐Escalating Bipartite Therapy (Glucocorticoids Combined With Tacrolimus) for Refractory MDA5 Antibody‐Positive Clinically Amyopathic Dermatomyositis With Rapidly Progressive Interstitial Pneumonia [PDF]
Immunity, Inflammation and DiseaseObjective This study aimed to determine the outcomes of patients that have refractory anti‐melanoma differentiation‐associated gene 5 (MDA5) antibody‐positive clinically amyopathic dermatomyositis with rapidly progressive interstitial pneumonia treated ...
Anji Xiong +10 more
doaj +2 more sources
Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis [PDF]
Frontiers in Pharmacology, 2023 Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs.
Jung Sun Kim +4 more
doaj +2 more sources
Machine learning approach for personalized vancomycin steady-state trough concentration prediction: a superior approach over Bayesian population pharmacokinetic model [PDF]
Frontiers in PharmacologyIntroductionAppropriate vancomycin trough levels are crucial for ensuring therapeutic efficacy while minimizing toxicity. The aim of this study is to identify clinical factors that influence the steady-state trough concentration of vancomycin and to ...
Ting Hu +3 more
doaj +2 more sources