Results 21 to 30 of about 2,565,891 (293)

Relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis

Di-san junyi daxue xuebao, 2020
Objective To investigate the relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis.
CHENG Lin, WENG Bangbi, XIANG Rongfeng, SUN Fengjun   +3 more
doaj   +1 more source

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

Frontiers in Pharmacology, 2022
Introduction: Therapeutic drug monitoring (TDM) and pharmacokinetic assessments of vancomycin would be essential to avoid vancomycin-associated nephrotoxicity and obtain optimal therapeutic and clinical responses.
Parisa Ghasemiyeh, Parisa Ghasemiyeh, Afsaneh Vazin, Farid Zand, Elham Haem, Iman Karimzadeh, Amir Azadi, Mansoor Masjedi, Golnar Sabetian, Reza Nikandish, Soliman Mohammadi-Samani, Soliman Mohammadi-Samani   +11 more
doaj   +1 more source

Inflammation Is Associated with Voriconazole Trough Concentrations [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-
van Wanrooy, Marjolijn J. P., Span, Lambert F. R., Rodgers, Michael G. G., van den Heuvel, Edwin R., Uges, Donald R. A., van der Werf, Tjip S., Kosterink, Jos G. W., Alffenaar, Jan-Willem C.   +7 more
openaire   +3 more sources

Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

Clinical and Translational Science, 2021
Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao, Xiao‐Bin Lin, Bi‐Kui Zhang, Yi‐wen Xiao, Ping Xu, Feng Wang, Da‐Xiong Xiang, Xu‐Biao Xie, Feng‐Hua Peng, Miao Yan   +9 more
doaj   +1 more source

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing? [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC).
Michael N, Neely, Gilmer, Youn, Brenda, Jones, Roger W, Jelliffe, George L, Drusano, Keith A, Rodvold, Thomas P, Lodise   +6 more
openaire   +2 more sources

Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

Pharmaceuticals, 2021
Small molecule kinase inhibitors (SMKIs) are widely used in oncology. Therapeutic drug monitoring (TDM) for SMKIs could reduce underexposure or overexposure.
Ruben A. G. van Eerden, Esther Oomen-de Hoop, Aad Noordam, Ron H. J. Mathijssen, Stijn L. W. Koolen   +4 more
doaj   +1 more source

Development of a cascaded latent heat storage system for parabolic trough solar thermal power generation [PDF]

, 2014
Concentrated solar power (CSP) has the potential of fulfilling the world’s electricity needs. Parabolic-trough system using synthetic oil as the HTF with operating temperature between 300 and 400o C, is the most matured CSP technology.
Muhammad, Mubarak Danladi
core   +7 more sources

A Large Sample Retrospective Study on the Distinction of Voriconazole Concentration in Asian Patients from Different Clinical Departments

Pharmaceuticals, 2021
Voriconazole (VRZ) is widely used to prevent and treat invasive fungal infections; however, there are a few studies examining the variability and influencing the factors of VRZ plasma concentrations across different clinical departments. This study aimed
Yichang Zhao, Chenlin Xiao, Jingjing Hou, Jiamin Wu, Yiwen Xiao, Bikui Zhang, Indy Sandaradura, Miao Yan   +7 more
doaj   +1 more source

Impact of renal replacement therapy strategy on beta-lactam plasma concentrations: the BETAKIKI study—an ancillary study of a randomized controlled trial

Annals of Intensive Care, 2023
Background Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage.
Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss, Stéphane Gaudry, for the AKIKI Study group   +17 more
doaj   +1 more source

Updating the traditional voriconazole trough concentration range [PDF]

The Lancet Infectious Diseases
Rongqiang, Liao, Xiaoyuan, Zheng
openaire   +3 more sources