Results 21 to 30 of about 52,480 (256)

Impact of renal replacement therapy strategy on beta-lactam plasma concentrations: the BETAKIKI study—an ancillary study of a randomized controlled trial

Annals of Intensive Care, 2023
Background Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage.
Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss, Stéphane Gaudry, for the AKIKI Study group   +17 more
doaj   +1 more source

Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 μg/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis

Journal of Fungi, 2021
This systematic review and meta-analysis examined the optimal trough concentration of voriconazole for adult patients with invasive fungal infections. We used stepwise cutoffs of 0.5–2.0 μg/mL for efficacy and 3.0–6.0 μg/mL for safety.
Yuki Hanai, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Yoshiko Takahashi, Satoshi Fujii, Kenji Nishizawa, Yoshitsugu Miyazaki, Yoshio Takesue   +8 more
doaj   +1 more source

A Regression Model to Predict Linezolid Induced Thrombocytopenia in Neonatal Sepsis Patients: A Ten-Year Retrospective Cohort Study

Frontiers in Pharmacology, 2022
Background: Linezolid-induced thrombocytopenia (LIT) is the main factor limiting the clinical application of linezolid (LZD). The incidence and risk factors of LIT in neonatal patients were possibly different from other populations based on ...
Lufen Duan, Qin Zhou, Zongtai Feng, Chenqi Zhu, Yan Cai, Sannan Wang, Meiying Zhu, Jingjing Li, Yunlong Yuan, Xin Liu, Jiantong Sun, Zuming Yang, Lian Tang   +12 more
doaj   +1 more source

Toward Therapeutic Drug Monitoring of Lenalidomide in Hematological Malignancy? Results of an Observational Study of the Exposure-Safety Relationship

Frontiers in Pharmacology, 2022
Objective: Continuous lenalidomide (LEN) therapy is important to achieve a therapeutic effect in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).
Zaiwei Song, Zaiwei Song, Lan Ma, Li Bao, Yi Ma, Yi Ma, Ping Yang, Ping Yang, Dan Jiang, Dan Jiang, Aijun Liu, Lu Zhang, Yan Li, Yinchu Cheng, Yinchu Cheng, Fei Dong, Rongsheng Zhao, Rongsheng Zhao, Hongmei Jing   +18 more
doaj   +1 more source

Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis

Pharmaceutics, 2022
Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity.
Sacha Sarfati, Julien Wils, Timothée Lambert, Céline Mory, Laurent Imbert, Gilles Gargala, Hélène Morisse-Pradier, Fabien Lamoureux   +7 more
doaj   +1 more source

Posaconazole trough concentrations are not influenced by inflammation: A prospective study

International Journal of Antimicrobial Agents, 2019
During inflammation, several cytochrome P450 enzymes are downregulated. Recently it was shown that voriconazole metabolism is reduced during inflammation. Posaconazole, another triazole with broad-spectrum antifungal activity, is metabolised only to a limited extent by cytochrome P450 enzymes and to a wider extent by phase 2 enzyme systems.
Märtson, Anne-Grete, Veringa, Anette, Bakker, Martijn, van den Heuvel, Edwin R., Touw, Daan J., van der Werf, Tjip S., Span, Lambert F.R., C. Alffenaar, Jan-Willem   +7 more
openaire   +2 more sources

Factors affecting serum concentration of dabigatran in Asian patients with non-valvular atrial fibrillation

Journal of the Formosan Medical Association, 2019
Background/purpose: Dabigatran is effective in preventing ischemic stroke and systemic embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is wide, its pharmacokinetic properties can differ between specific ...
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Kai Tsai, Shin-Joe Yeh, Li-Jiuan Shen, Jiann-Shing Jeng   +6 more
doaj   +1 more source

Evaluation of the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit

International Journal of Infectious Diseases, 2017
Objective: To examine the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit (ICU) and to analyze the factors influencing the trough concentration.
Xiaodan Qian, Guantao Du, Chunmei Weng, Haijun Zhou, Xianju Zhou   +4 more
doaj   +1 more source

The relationship of vancomycin 24-hour AUC and trough concentration

American Journal of Health-System Pharmacy, 2021
Abstract Purpose Prior to the 2020 release of a joint consensus guideline on monitoring of vancomycin therapy for serious methicillin-resistant Staphylococcus aureus (MRSA) infections, clinicians had escalated vancomycin doses for 2 decades while targeting trough concentrations of 15 to 20 µg/mL ...
David E Nix, Lisa E Davis, Kathryn R Matthias   +2 more
openaire   +2 more sources

Intracellular and Plasma Trough Concentration and Pharmacogenetics of Telaprevir

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: Triple therapy for HCV-1 infection consists in boceprevir or telaprevir, ribavirin and PEG-interferon. Telaprevir is a P-glycoprotein substrate and it is metabolized by CYP3A4/5. No data have been published on intracellular penetration of telaprevir.
CUSATO, JESSICA, ALLEGRA, SARAH, DE NICOLO', AMEDEO, BOGLIONE, Lucio, FATIGUSO, GIOVANNA, Mohamed Abdi, Adnan, Cariti, Giuseppe, DI PERRI, Giovanni, D'AVOLIO, ANTONIO   +8 more
openaire   +5 more sources