Results 21 to 30 of about 57,485 (298)

Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis

Pharmaceutics, 2022
Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity.
Sacha Sarfati, Julien Wils, Timothée Lambert, Céline Mory, Laurent Imbert, Gilles Gargala, Hélène Morisse-Pradier, Fabien Lamoureux   +7 more
doaj   +1 more source

Relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis

Di-san junyi daxue xuebao, 2020
Objective To investigate the relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis.
CHENG Lin, WENG Bangbi, XIANG Rongfeng, SUN Fengjun   +3 more
doaj   +1 more source

Inflammation Is Associated with Voriconazole Trough Concentrations [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-
van Wanrooy, Marjolijn J. P., Span, Lambert F. R., Rodgers, Michael G. G., van den Heuvel, Edwin R., Uges, Donald R. A., van der Werf, Tjip S., Kosterink, Jos G. W., Alffenaar, Jan-Willem C.   +7 more
openaire   +3 more sources

A new configuration of V-trough concentrator for achieving improved concentration ratio of >3.0x [PDF]

, 2022
A new configuration of V-trough solar concentrator is proposed, constructed and investigated in an attempt to improve the concentration ratio of the V-trough concentrators.
Gao, Min, Alnajideen, Mohammad
core   +1 more source

Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

Clinical and Translational Science, 2021
Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao, Xiao‐Bin Lin, Bi‐Kui Zhang, Yi‐wen Xiao, Ping Xu, Feng Wang, Da‐Xiong Xiang, Xu‐Biao Xie, Feng‐Hua Peng, Miao Yan   +9 more
doaj   +1 more source

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

Frontiers in Pharmacology, 2022
Introduction: Therapeutic drug monitoring (TDM) and pharmacokinetic assessments of vancomycin would be essential to avoid vancomycin-associated nephrotoxicity and obtain optimal therapeutic and clinical responses.
Parisa Ghasemiyeh, Parisa Ghasemiyeh, Afsaneh Vazin, Farid Zand, Elham Haem, Iman Karimzadeh, Amir Azadi, Mansoor Masjedi, Golnar Sabetian, Reza Nikandish, Soliman Mohammadi-Samani, Soliman Mohammadi-Samani   +11 more
doaj   +1 more source

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing? [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC).
Michael N, Neely, Gilmer, Youn, Brenda, Jones, Roger W, Jelliffe, George L, Drusano, Keith A, Rodvold, Thomas P, Lodise   +6 more
openaire   +2 more sources

The dayside high-latitude trough under quiet geomagnetic conditions: Radio tomography and the CTIP model [PDF]

, 2005
International audienceThe dayside high-latitude trough is a persistent feature of the post-noon wintertime auroral ionosphere. Radio tomography observations have been used to map its location and latitudinal structure under quiet geomagnetic conditions ...
Dewis, K. L., Denton, M.H., Pryse, S. E., Balthazor, R. L., Middleton, H. R., Balthazor, R.L., H. R. Middleton, Dewis, K.L., R. L. Balthazor, Denton, M. H., S. E. Pryse, Pryse, S.E., Middleton, H.R., K. L. Dewis, M. H. Denton   +14 more
core   +1 more source

Impact of renal replacement therapy strategy on beta-lactam plasma concentrations: the BETAKIKI study—an ancillary study of a randomized controlled trial

Annals of Intensive Care, 2023
Background Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage.
Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss, Stéphane Gaudry, for the AKIKI Study group   +17 more
doaj   +1 more source

Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species. [PDF]

BMC Infect Dis, 2021
Background: Pharmacokinetic-pharmacodynamic (PK/PD) targets of vancomycin therapy have been recognized for methicillin-resistant Staphylococcus aureus infections but not for other gram-positive bacterial infections.
Sohn Y, Rim JH, Cho Y, Hyun J, Baek Y, Kim M, Kim JH, Seong H, Ahn JY, Lee SG, Lim JB, Jeong SJ, Ku NS, Choi JY, Yeom JS, Song YG.   +15 more
europepmc   +2 more sources