Results 31 to 40 of about 57,485 (298)

Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 μg/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis

Journal of Fungi, 2021
This systematic review and meta-analysis examined the optimal trough concentration of voriconazole for adult patients with invasive fungal infections. We used stepwise cutoffs of 0.5–2.0 μg/mL for efficacy and 3.0–6.0 μg/mL for safety.
Yuki Hanai, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Yoshiko Takahashi, Satoshi Fujii, Kenji Nishizawa, Yoshitsugu Miyazaki, Yoshio Takesue   +8 more
doaj   +1 more source

Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse Reactions in Epidermal Growth Factor Receptor–Mutated Non-Small Cell Lung Cancer Patients

Frontiers in Pharmacology, 2020
BackgroundErlotinib is presently the first line treatment for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) active mutation.
Dehua Liao, Dehua Liao, Zhigang Liu, Yongchang Zhang, Ni Liu, Dunwu Yao, Lizhi Cao, Yun Chen, Yilan Fu, Nong Yang, Daxiong Xiang   +10 more
doaj   +1 more source

A Regression Model to Predict Linezolid Induced Thrombocytopenia in Neonatal Sepsis Patients: A Ten-Year Retrospective Cohort Study

Frontiers in Pharmacology, 2022
Background: Linezolid-induced thrombocytopenia (LIT) is the main factor limiting the clinical application of linezolid (LZD). The incidence and risk factors of LIT in neonatal patients were possibly different from other populations based on ...
Lufen Duan, Qin Zhou, Zongtai Feng, Chenqi Zhu, Yan Cai, Sannan Wang, Meiying Zhu, Jingjing Li, Yunlong Yuan, Xin Liu, Jiantong Sun, Zuming Yang, Lian Tang   +12 more
doaj   +1 more source

He+ dominance in the plasmasphere during geomagnetically disturbed periods: 1. Observational results [PDF]

, 2002
Observations made by the DMSP 1710 satellite during the recovery phase from geomagnetic disturbances in June 1991 show regions of He+ dominance around 830 km altitude at 09:00 MLT.
Wilford, C. R., Bailey, G.J., G. J. Bailey, Denton, M.H., Bailey, G. J., Wilford, C.R., Rodger, A. S., Rodger, A.S., Venkatraman, S., Denton, M. H., C. R. Wilford, A. S. Rodger, S. Venkatraman, M. H. Denton   +13 more
core   +1 more source

High-Trough Plasma Concentration of Afatinib Is Associated with Dose Reduction

, 2021
Afatinib is used to treat non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation as a second-generation EGFR-tyrosine kinase inhibitor (TKI).
Takayuki Takahashi, Takayuki Suetsugu, Ryuji Ikeda, Hideki Sugawara, Hiromasa Inoue, Yasuo Takeda, Hideyuki Terazono, Junko Arima, Keiko Mizuno, Mina Nitta, Toru Tanabe, Kayu Okutsu   +11 more
core   +1 more source

Toward Therapeutic Drug Monitoring of Lenalidomide in Hematological Malignancy? Results of an Observational Study of the Exposure-Safety Relationship

Frontiers in Pharmacology, 2022
Objective: Continuous lenalidomide (LEN) therapy is important to achieve a therapeutic effect in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).
Zaiwei Song, Zaiwei Song, Lan Ma, Li Bao, Yi Ma, Yi Ma, Ping Yang, Ping Yang, Dan Jiang, Dan Jiang, Aijun Liu, Lu Zhang, Yan Li, Yinchu Cheng, Yinchu Cheng, Fei Dong, Rongsheng Zhao, Rongsheng Zhao, Hongmei Jing   +18 more
doaj   +1 more source

Posaconazole trough concentrations are not influenced by inflammation: A prospective study

International Journal of Antimicrobial Agents, 2019
During inflammation, several cytochrome P450 enzymes are downregulated. Recently it was shown that voriconazole metabolism is reduced during inflammation. Posaconazole, another triazole with broad-spectrum antifungal activity, is metabolised only to a limited extent by cytochrome P450 enzymes and to a wider extent by phase 2 enzyme systems.
Märtson, Anne-Grete, Veringa, Anette, Bakker, Martijn, van den Heuvel, Edwin R., Touw, Daan J., van der Werf, Tjip S., Span, Lambert F.R., C. Alffenaar, Jan-Willem   +7 more
openaire   +2 more sources

Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

Pharmaceuticals, 2021
Small molecule kinase inhibitors (SMKIs) are widely used in oncology. Therapeutic drug monitoring (TDM) for SMKIs could reduce underexposure or overexposure.
Ruben A. G. van Eerden, Esther Oomen-de Hoop, Aad Noordam, Ron H. J. Mathijssen, Stijn L. W. Koolen   +4 more
doaj   +1 more source

Intracellular and Plasma Trough Concentration and Pharmacogenetics of Telaprevir

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: Triple therapy for HCV-1 infection consists in boceprevir or telaprevir, ribavirin and PEG-interferon. Telaprevir is a P-glycoprotein substrate and it is metabolized by CYP3A4/5. No data have been published on intracellular penetration of telaprevir.
CUSATO, JESSICA, ALLEGRA, SARAH, DE NICOLO', AMEDEO, BOGLIONE, Lucio, FATIGUSO, GIOVANNA, Mohamed Abdi, Adnan, Cariti, Giuseppe, DI PERRI, Giovanni, D'AVOLIO, ANTONIO   +8 more
openaire   +4 more sources

Evaluation of the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit

International Journal of Infectious Diseases, 2017
Objective: To examine the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit (ICU) and to analyze the factors influencing the trough concentration.
Xiaodan Qian, Guantao Du, Chunmei Weng, Haijun Zhou, Xianju Zhou   +4 more
doaj   +1 more source