Results 11 to 20 of about 2,565,891 (293)

Variability of Tacrolimus Trough Concentration in Liver Transplant Patients: Which Role of Inflammation?

Pharmaceutics, 2021
Tacrolimus presents high intra and inter-individual variability in its blood trough concentration (Cmin). Knowledge of the factors that are involved in tacrolimus Cmin variability is thus clinically important to prevent or limit it.
Anaelle Chavant, Xavier Fonrose, Elodie Gautier-Veyret, Marie Noelle Hilleret, Matthieu Roustit, Francoise Stanke-Labesque   +5 more
doaj   +3 more sources

The relationship of vancomycin 24-hour AUC and trough concentration

American Journal of Health-System Pharmacy, 2021
Abstract Purpose Prior to the 2020 release of a joint consensus guideline on monitoring of vancomycin therapy for serious methicillin-resistant Staphylococcus aureus (MRSA) infections, clinicians had escalated vancomycin doses for 2 decades while targeting trough concentrations of 15 to 20 µg/mL ...
David E Nix, Lisa E Davis, Kathryn R Matthias   +2 more
openaire   +3 more sources

The relationship between vancomycin AUC/MIC and trough concentration, age, dose, renal function in Chinese critically ill pediatric patients

Pharmacology Research & Perspectives, 2021
To assess the pharmacokinetic parameters of vancomycin in Chinese critically ill pediatric patients, children treated with vancomycin, hospitalized in the intensive care unit were included.
Jihui Chen, Xiaohui Huang, Shuhong Bu, Xiaoxiao Chen, Jia Zhou, Xinzhu Liu, Xiaowen Guo, Lixia Li, Jian Zhang   +8 more
doaj   +2 more sources

Discordance between trough concentration and tacrolimus exposure on the day of kidney transplantation: a prospective pharmacokinetic study [PDF]

Frontiers in Pharmacology
Tacrolimus trough concentration (C0) serves as a surrogate for drug exposure, but perioperative factors may disrupt this relationship early post-transplantation.
Hye Eun Kwon, Jin-Myung Kim, Youngmin Ko, Sung Shin, Young Hoon Kim, Joo Hee Jung, Chung Hee Baek, Hyosang Kim, Hyunwook Kwon   +8 more
doaj   +2 more sources

Predictors of target initial teicoplanin trough concentration attainment in patients with hematological malignancies: a retrospective cohort study

Journal of Pharmaceutical Health Care and Sciences
Background Teicoplanin (TEIC) is frequently used at Osaka Metropolitan University Hospital to treat infections caused by gram-positive cocci in patients with hematological malignancies.
Kazuki Deguchi, Norihiro Sakurai, Toya Matsui, Mayuko Itoya, Makoto Miyoshi, Hiroshi Kawaguchi, Yasutaka Nakamura   +6 more
doaj   +2 more sources

The dayside high-latitude trough under quiet geomagnetic conditions: Radio tomography and the CTIP model [PDF]

, 2005
International audienceThe dayside high-latitude trough is a persistent feature of the post-noon wintertime auroral ionosphere. Radio tomography observations have been used to map its location and latitudinal structure under quiet geomagnetic conditions ...
Dewis, K. L., Denton, M.H., Pryse, S. E., Balthazor, R. L., Middleton, H. R., Balthazor, R.L., H. R. Middleton, Dewis, K.L., R. L. Balthazor, Denton, M. H., S. E. Pryse, Pryse, S.E., Middleton, H.R., K. L. Dewis, M. H. Denton   +14 more
core   +6 more sources

Is It Still Beneficial to Monitor the Trough Concentration of Vancomycin? A Quantitative Meta-Analysis of Nephrotoxicity and Efficacy

Antibiotics
This study conducted a quantitative meta-analysis to investigate the association of vancomycin indicators, particularly area under the curve over 24 h (AUC24) and trough concentrations (Ctrough), and their relationship with both nephrotoxicity and ...
Wanqiu Yang, Kaiting Zhang, Yuancheng Chen, Yaxin Fan, Jing Zhang   +4 more
doaj   +3 more sources

C/MIC > 4: A Potential Instrument to Predict the Efficacy of Meropenem

Antibiotics, 2022
This prospective study aimed to explore the determinants of meropenem trough concentration (Ctrough) in patients with bacterial pneumonia and to investigate the association between its concentration and efficacy.
Yichang Zhao, Chenlin Xiao, Jingjing Hou, Jiamin Wu, Yiwen Xiao, Bikui Zhang, Indy Sandaradura, Hong Luo, Jinhua Li, Miao Yan   +9 more
doaj   +1 more source

Correction: Correlation analysis of cyclosporine a trough concentration with hematological and biochemical parameters: a retrospective study in pediatric aplastic anemia [PDF]

Frontiers in Pediatrics
Qian Xu, Xintong Mao, Yi Yun, Ling Liu
doaj   +2 more sources

Pharmacokinetic Variability and Target Attainment of Fluconazole in Critically Ill Patients

Microorganisms, 2021
Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target attainment in critically ill patients.
Ruth Van Daele, Joost Wauters, Katrien Lagrou, Raphaël Denooz, Marie-Pierre Hayette, Matthias Gijsen, Roger J. Brüggemann, Yves Debaveye, Isabel Spriet   +8 more
doaj   +1 more source