Results 11 to 20 of about 52,480 (256)

Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis [PDF]

Frontiers in Pharmacology, 2023
Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs.
Jung Sun Kim, Sunyoung Shim, Jeong Yee, Kyung Hee Choi, Hye Sun Gwak   +4 more
doaj   +2 more sources

Vancomycin therapeutic monitoring by measured trough concentration versus Bayesian‐derived area under the curve in critically ill patients with cancer [PDF]

Pharmacology Research & Perspectives, 2022
The updated vancomycin guideline and recent studies suggested that trough concentrations may result in underestimation of the actual area under the curve (AUC), leading to excessive dosing and nephrotoxicity. With limited data available on critically ill
Aseel K. AbuSara, Deema H. Abdelrahman, Khader I. Habash, Mohammad H. Al‐Shaer, Jennifer Le, Lama H. Nazer   +5 more
doaj   +2 more sources

Is It Still Beneficial to Monitor the Trough Concentration of Vancomycin? A Quantitative Meta-Analysis of Nephrotoxicity and Efficacy [PDF]

Antibiotics
This study conducted a quantitative meta-analysis to investigate the association of vancomycin indicators, particularly area under the curve over 24 h (AUC24) and trough concentrations (Ctrough), and their relationship with both nephrotoxicity and ...
Wanqiu Yang, Kaiting Zhang, Yuancheng Chen, Yaxin Fan, Jing Zhang   +4 more
doaj   +2 more sources

C/MIC > 4: A Potential Instrument to Predict the Efficacy of Meropenem

Antibiotics, 2022
This prospective study aimed to explore the determinants of meropenem trough concentration (Ctrough) in patients with bacterial pneumonia and to investigate the association between its concentration and efficacy.
Yichang Zhao, Chenlin Xiao, Jingjing Hou, Jiamin Wu, Yiwen Xiao, Bikui Zhang, Indy Sandaradura, Hong Luo, Jinhua Li, Miao Yan   +9 more
doaj   +1 more source

Pharmacokinetic Variability and Target Attainment of Fluconazole in Critically Ill Patients

Microorganisms, 2021
Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target attainment in critically ill patients.
Ruth Van Daele, Joost Wauters, Katrien Lagrou, Raphaël Denooz, Marie-Pierre Hayette, Matthias Gijsen, Roger J. Brüggemann, Yves Debaveye, Isabel Spriet   +8 more
doaj   +1 more source

Relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis

Di-san junyi daxue xuebao, 2020
Objective To investigate the relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis.
CHENG Lin, WENG Bangbi, XIANG Rongfeng, SUN Fengjun   +3 more
doaj   +1 more source

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

Frontiers in Pharmacology, 2022
Introduction: Therapeutic drug monitoring (TDM) and pharmacokinetic assessments of vancomycin would be essential to avoid vancomycin-associated nephrotoxicity and obtain optimal therapeutic and clinical responses.
Parisa Ghasemiyeh, Parisa Ghasemiyeh, Afsaneh Vazin, Farid Zand, Elham Haem, Iman Karimzadeh, Amir Azadi, Mansoor Masjedi, Golnar Sabetian, Reza Nikandish, Soliman Mohammadi-Samani, Soliman Mohammadi-Samani   +11 more
doaj   +1 more source

Inflammation Is Associated with Voriconazole Trough Concentrations [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-
van Wanrooy, Marjolijn J. P., Span, Lambert F. R., Rodgers, Michael G. G., van den Heuvel, Edwin R., Uges, Donald R. A., van der Werf, Tjip S., Kosterink, Jos G. W., Alffenaar, Jan-Willem C.   +7 more
openaire   +3 more sources

Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

Clinical and Translational Science, 2021
Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao, Xiao‐Bin Lin, Bi‐Kui Zhang, Yi‐wen Xiao, Ping Xu, Feng Wang, Da‐Xiong Xiang, Xu‐Biao Xie, Feng‐Hua Peng, Miao Yan   +9 more
doaj   +1 more source

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing? [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC).
Michael N, Neely, Gilmer, Youn, Brenda, Jones, Roger W, Jelliffe, George L, Drusano, Keith A, Rodvold, Thomas P, Lodise   +6 more
openaire   +2 more sources