The relationship of vancomycin 24-hour AUC and trough concentration
American Journal of Health-System Pharmacy, 2021 Abstract Purpose Prior to the 2020 release of a joint consensus guideline on monitoring of vancomycin therapy for serious methicillin-resistant Staphylococcus aureus (MRSA) infections, clinicians had escalated vancomycin doses for 2 decades while targeting trough concentrations of 15 to 20 µg/mL ...
David E Nix +2 more
openaire +3 more sources
Machine learning approach for personalized vancomycin steady-state trough concentration prediction: a superior approach over Bayesian population pharmacokinetic model [PDF]
Frontiers in PharmacologyIntroductionAppropriate vancomycin trough levels are crucial for ensuring therapeutic efficacy while minimizing toxicity. The aim of this study is to identify clinical factors that influence the steady-state trough concentration of vancomycin and to ...
Ting Hu +3 more
doaj +2 more sources
Clinical and genetic determinants of nevirapine plasma trough concentration [PDF]
SAGE Open Medicine, 2018 Background: Only few data are available on the influence of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations in the Caucasian population. Our aim was to assess the impact of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations consecutively collected.
Giacomelli, Andrea +12 more
openaire +5 more sources
Vancomycin therapeutic monitoring by measured trough concentration versus Bayesian‐derived area under the curve in critically ill patients with cancer [PDF]
Pharmacology Research & Perspectives, 2022 The updated vancomycin guideline and recent studies suggested that trough concentrations may result in underestimation of the actual area under the curve (AUC), leading to excessive dosing and nephrotoxicity. With limited data available on critically ill
Aseel K. AbuSara +5 more
doaj +2 more sources
Is It Still Beneficial to Monitor the Trough Concentration of Vancomycin? A Quantitative Meta-Analysis of Nephrotoxicity and Efficacy [PDF]
AntibioticsThis study conducted a quantitative meta-analysis to investigate the association of vancomycin indicators, particularly area under the curve over 24 h (AUC24) and trough concentrations (Ctrough), and their relationship with both nephrotoxicity and ...
Wanqiu Yang +4 more
doaj +2 more sources
Cytokine Profile at Diagnosis Affecting Trough Concentration of Infliximab in Pediatric Crohn's Disease. [PDF]
Biomedicines, 2022 Background: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn’s disease and to determine if the initial tumor ...
Kwon Y, Kim ES, Kim YZ, Choe YH, Kim MJ.
europepmc +2 more sources
C/MIC > 4: A Potential Instrument to Predict the Efficacy of Meropenem
Antibiotics, 2022 This prospective study aimed to explore the determinants of meropenem trough concentration (Ctrough) in patients with bacterial pneumonia and to investigate the association between its concentration and efficacy.
Yichang Zhao +9 more
doaj +1 more source
Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients. [PDF]
Drug Des Devel TherAymen Ali Alqurain,1 Laila Nasser Alrashidi,2 Shatha Khalid Aloraifej,2 Moayd Alkhalifah,3 Hawra Ali Alsayed,4 Salah Abohelaika,5,6 Mohammad A Alshabeeb,7,8 Amal Shibak Aldhafeeri,9 Moyad Almuslim,10 Thuraya Nasser Bumozah,11 Mukhtar Jawad Alomar,12 ...
Alqurain AA +15 more
europepmc +2 more sources
Factors Affecting Voriconazole Trough Concentration and Optimal Maintenance Voriconazole Dose in Chinese Children. [PDF]
Antibiotics (Basel), 2021 Voriconazole is a triazole antifungal agent commonly used for the treatment and prevention of invasive aspergillosis (IA). However, the study of voriconazole\u27s use in children is limited.
Zhao YC +8 more
europepmc +2 more sources
Pharmacokinetic Variability and Target Attainment of Fluconazole in Critically Ill Patients
Microorganisms, 2021 Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target attainment in critically ill patients.
Ruth Van Daele +8 more
doaj +1 more source