Results 41 to 50 of about 2,565,891 (293)

Factors affecting serum concentration of dabigatran in Asian patients with non-valvular atrial fibrillation

Journal of the Formosan Medical Association, 2019
Background/purpose: Dabigatran is effective in preventing ischemic stroke and systemic embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is wide, its pharmacokinetic properties can differ between specific ...
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Kai Tsai, Shin-Joe Yeh, Li-Jiuan Shen, Jiann-Shing Jeng   +6 more
doaj   +1 more source

Association between pazopanib exposure and safety in Japanese patients with renal cell carcinoma or soft tissue sarcoma

Scientific Reports, 2023
The safety and effectiveness of pazopanib are related to plasma trough concentrations in renal cell carcinoma (RCC); however, data on pazopanib plasma trough concentrations with soft tissue sarcoma (STS) are limited.
Takeshi Aoyama, Kenji Nakano, Takeshi Yuasa, Erika Sugiyama, Takako Okawa, Kazuyuki Ito, Keiichi Azuma, Koki Hashimoto, Ryota Furutani, Makoto Hiraide, Kazuo Kobayashi, Kenichi Suzuki, Jyunnichi Tomomatsu, Masataka Tajima, Hitoshi Sato, Toshihiro Hama, Shunji Takahashi   +16 more
doaj   +1 more source

Evaluation of the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit

International Journal of Infectious Diseases, 2017
Objective: To examine the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit (ICU) and to analyze the factors influencing the trough concentration.
Xiaodan Qian, Guantao Du, Chunmei Weng, Haijun Zhou, Xianju Zhou   +4 more
doaj   +1 more source

Intracellular and Plasma Trough Concentration and Pharmacogenetics of Telaprevir

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: Triple therapy for HCV-1 infection consists in boceprevir or telaprevir, ribavirin and PEG-interferon. Telaprevir is a P-glycoprotein substrate and it is metabolized by CYP3A4/5. No data have been published on intracellular penetration of telaprevir.
CUSATO, JESSICA, ALLEGRA, SARAH, DE NICOLO', AMEDEO, BOGLIONE, Lucio, FATIGUSO, GIOVANNA, Mohamed Abdi, Adnan, Cariti, Giuseppe, DI PERRI, Giovanni, D'AVOLIO, ANTONIO   +8 more
openaire   +6 more sources

A real-world study of the optimal cut-off value for vancomycin trough concentration associated with outcomes in children infected with drug-resistant Gram-positive bacteria

Frontiers in Pediatrics
BackgroundDue to a lack of studies on the relationship between vancomycin trough concentration and clinical outcomes in pediatric patients, there is insufficient evidence to provide a unified standard for vancomycin trough concentration for children ...
Yinghui Yan, Manli Wang, Mi Zhou, Jingxing Yang, Jingxing Yang, Zengyan Zhu, Fengjiao Wang   +6 more
doaj   +1 more source

A new configuration of V-trough concentrator for achieving improved concentration ratio of >3.0x [PDF]

, 2022
A new configuration of V-trough solar concentrator is proposed, constructed and investigated in an attempt to improve the concentration ratio of the V-trough concentrators.
Gao, Min, Alnajideen, Mohammad
core   +1 more source

Factors influencing vancomycin trough concentration in burn patients: a single center retrospective study

Frontiers in Pharmacology
ObjectiveTo analyze factors influencing the vancomycin trough concentration in burn patients to provide a basis for the more rational use of vancomycin in these patients.Materials and methodsWe collected the clinical data of adult burn patients treated ...
Yan Shi, Zongqi Yin, Qin Zhang, Lei Yi, Yi Dou   +4 more
doaj   +1 more source

Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration

Dose-Response
Objective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood
Lin Wang, Yuhuang Wang, Chunyan Yang, Jia Jiang, Huifang Wang, Mingcai Wu   +5 more
doaj   +1 more source

dnarkevi/lb-trough-data-analyser: Initial release

, 2023
Repository for Langmuir–Blodgett trough data analyser program and the source ...
Domantas Narkevičius
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source