Results 21 to 30 of about 171,760 (178)

On the use of thermal conductive focusing for solar concentration enhancement [PDF]

, 2016
© 2016. This version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/We discuss the possibility for solar concentration enhancement via conductive heat transport. Here, we are concerned, as in orthodox
Arias Montenegro, Francisco Javier
core   +2 more sources

Impact of renal replacement therapy strategy on beta-lactam plasma concentrations: the BETAKIKI study—an ancillary study of a randomized controlled trial

Annals of Intensive Care, 2023
Background Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage.
Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss, Stéphane Gaudry, for the AKIKI Study group   +17 more
doaj   +1 more source

Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 μg/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis

Journal of Fungi, 2021
This systematic review and meta-analysis examined the optimal trough concentration of voriconazole for adult patients with invasive fungal infections. We used stepwise cutoffs of 0.5–2.0 μg/mL for efficacy and 3.0–6.0 μg/mL for safety.
Yuki Hanai, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Yoshiko Takahashi, Satoshi Fujii, Kenji Nishizawa, Yoshitsugu Miyazaki, Yoshio Takesue   +8 more
doaj   +1 more source

Clinical consequences of antibody formation, serum concentrations, and HLA-Cw6 status in psoriasis patients on Ustekinumab [PDF]

, 2019
Background: Ustekinumab for the treatment of psoriasis is currently administered in a standard dosing regimen. However, some patients tend to benefit from alternative dosing regimens, a step toward personalized medicine.
Busard, Celine, I, Costanzo, Antonio, De Keyser, Eline, Hutten, Barbara A., Lambert, Jo, Lanssens, Sven, Meuleman, Lieve, Spuls, Phyllis, I, van den Reek, Juul M., Zweegers, Jeffrey   +9 more
core   +1 more source

Weight‐based tacrolimus trough concentrations post liver transplant [PDF]

Internal Medicine Journal, 2019
AbstractBackgroundTacrolimus is one of the most widely used liver transplant medications. With the increasing number of obese patients requiring liver transplants, knowledge of the effect of body size affecting post‐transplant outcomes, for example drug exposure is increasingly required.Aims(i) To investigate whether patient body size (i.e.
Zheng Liu, Jeffrey Cheng, Elizabeth Powell, Graeme Macdonald, Jonathan Fawcett, Stephen Lynch, Jennifer Martin   +6 more
openaire   +3 more sources

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing? [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC).
Michael N, Neely, Gilmer, Youn, Brenda, Jones, Roger W, Jelliffe, George L, Drusano, Keith A, Rodvold, Thomas P, Lodise   +6 more
openaire   +2 more sources

Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse Reactions in Epidermal Growth Factor Receptor–Mutated Non-Small Cell Lung Cancer Patients

Frontiers in Pharmacology, 2020
BackgroundErlotinib is presently the first line treatment for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) active mutation.
Dehua Liao, Dehua Liao, Zhigang Liu, Yongchang Zhang, Ni Liu, Dunwu Yao, Lizhi Cao, Yun Chen, Yilan Fu, Nong Yang, Daxiong Xiang   +10 more
doaj   +1 more source

Clinical performance of an infliximab rapid quantification assay [PDF]

, 2017
Background: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients.
Afonso, Joana, Andrade, Patrícia, Caldeira, Paulo, Carneiro, Fátima, Carvalho, Diana, Coelho, Rosa, Dias, Cláudia Camila, Geboes, Karel, Gonçalves, Ana Rita, Gonçalves, Raquel, Lago, Paula, Lopes, Joanne, Lopes, Susana, Magro, Fernando, Meira, Tania, Ministro, Paula, Ramos, Jaime, Rosa, Isadora, Soares, João-Bruno, Sousa, Helena Tavares, Sousa, Paula, Vieira, Ana Isabel   +21 more
core   +2 more sources

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

BMC Infectious Diseases, 2020
Background The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data ...
Yuyan Pan, Xiaomei He, Xinyu Yao, Xiaofeng Yang, Fengjiao Wang, Xinyuan Ding, Wenjuan Wang   +6 more
doaj   +1 more source

The relationship between vancomycin AUC/MIC and trough concentration, age, dose, renal function in Chinese critically ill pediatric patients

Pharmacology Research & Perspectives, 2021
To assess the pharmacokinetic parameters of vancomycin in Chinese critically ill pediatric patients, children treated with vancomycin, hospitalized in the intensive care unit were included.
Jihui Chen, Xiaohui Huang, Shuhong Bu, Xiaoxiao Chen, Jia Zhou, Xinzhu Liu, Xiaowen Guo, Lixia Li, Jian Zhang   +8 more
doaj   +1 more source