Results 211 to 220 of about 163,766 (299)

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor. [PDF]

J Org Chem
Gregorc J, De Neve J, Guitot K, Holleran BJ, Lensen N, Gendron L, Brigaud T, Iskra J, Ballet S, Chaume G.   +9 more
europepmc   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Biomarkers of oxidative damage as a tool to investigate frailty syndrome in older women. [PDF]

NPJ Aging
Sepúlveda M, Palomo I, Lagos F, Pardo X, López-Alarcón C, Ávila F, Fuentes E.   +6 more
europepmc   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Structure-Activity Relationship Study of Antimicrobial Peptide with Cross-Kingdom Activity. [PDF]

Biochemistry
Palakkurussi Rathessan A, Ghazisaeedi F, Unmesh K, Bingül PK, Kupke J, Chowdhary S, Hanke D, Mroginski MA, Fulde M, Koksch B.   +9 more
europepmc   +1 more source

Biomimetic TME‐Responsive Nanotheranostics for Precise NIR‐II Ratiometric Photoacoustic Imaging and Synergistic Immuno‐Photothermal Therapy

Small, EarlyView.
A biomimetic Au/Ag@HMON‐NLG@CCM nanotheranostic is engineered for tumor microenvironment‐responsive NIR‐II ratiometric photoacoustic imaging and immune‐photothermal therapy. The integration of hyperthermia‐triggered immunogenic cell death with IDO‐blockade‐mediated metabolic remodeling promotes dendritic cell maturation and T‐cell activation.
Xin Li, Hongrui Qiu, Lik Hang Hugo Tse, Xuehan Wang, Hsuan Lo, Huili Wang, Qi Li, Shiying Li, Yanjuan Gu, Wing‐tak Wong   +9 more
wiley   +1 more source

Role of TRPM4 ion channel in pediatric arrhythmic syndromes. [PDF]

World J Clin Pediatr
Melnik OV, Kulichik OE, Zaytseva AK, Kofeynikova OA, Fetisova SG, Tarnovskaya SI, Fomicheva YV, Vasichkina ES, Zhorov BS, Kalinina OV, Kostareva AA.   +10 more
europepmc   +1 more source

Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non‐small cell lung cancer cells: A drug repurposing study

Smart Molecules, EarlyView.
This study presents Delafloxacin repurposed as a DEPDC1‐targeting therapeutic aiming to suppress lung cancer progression. It highlights a novel strategy for lung cancer treatment with potential clinical applications. Abstract Emerging evidence highlights the oncogenic role of the Dishevelled, Egl‐10, and Pleckstrin domains containing 1 (DEPDC1) gene in
Noman Ali, Farishta Shafiq, Mishal Iftikhar, Muhammad Shahzad Zafar, Muhammad Shoaib   +4 more
wiley   +1 more source

Active subspace learning for coarse-grained molecular dynamics. [PDF]

J Chem Phys
Wojnar A, Pankavich S, Pak AJ.
europepmc   +1 more source

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source