Results 211 to 220 of about 176,809 (302)

Exact Methods for the Cumulative Capacitated Vehicle Routing Problem With Time Windows

Networks, EarlyView.
ABSTRACT This article studies the cumulative capacitated vehicle routing problem with time windows (CCVRPTW). The CCVRPTW consists of deciding the routing schedules for a set of homogeneous capacitated vehicles such that the latency, that is, the sum of the service start times at the customers, is minimized and the time windows as well as the vehicle ...
Alan Osorio‐Mora, Timo Gschwind
wiley   +1 more source

Developing CHARMM Force Field Parameters for the Radical States of Tryptophan and Tyrosine. [PDF]

J Chem Theory Comput
Kostritski AY, Hungerland J, Schuster C, Solov'yov IA.   +3 more
europepmc   +1 more source

TP53 mutations orchestrate partial EMT states in oral squamous cell carcinoma: spatially resolved and in vitro preliminary insights into tumour plasticity

The Journal of Pathology, EarlyView.
Abstract TP53 is the most frequently mutated gene in oral squamous cell carcinoma (OSCC); however, its role in promoting epithelial–mesenchymal transition (EMT) and tumour progression remains unclear, particularly within the context of intra‐tumour heterogeneity.
Rana Alaaeldin Ibrahim, Hong Wan, Raju Kumar, Muy‐Teck Teh, Angray Kang, Emma Bailey, Hannah Cottom, Adrian Biddle, Inês Sequeira, Farida Fortune   +9 more
wiley   +1 more source

Diminished Maternal Tryptophan Leads to Sexually Dimorphic Differences in the Placenta-Brain Axis. [PDF]

Nutrients
Herrington RTB, Lyu Z, Seda SE, Boling EE, Goldstein AK, Bivens NJ, Lei Z, Islam T, Sumner LW, Joshi T, Rosenfeld CS.   +10 more
europepmc   +1 more source

Recurrence of Breast Cancer With Scalp Metastasis

The Kaohsiung Journal of Medical Sciences, EarlyView.
Yi‐Nan Zhu, Wan‐Chen Lu, Zi‐Yue Wang, Xu‐Yong Lin   +3 more
wiley   +1 more source

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Dosimetric risk factors for therapy‐related pneumonitis in patients with immunotherapy plus chemotherapy concurrent thoracic radiotherapy

Precision Radiation Oncology, EarlyView.
In this study, mean lung dose (MLD) and age were associated with an increased risk of treatment‐related pneumonitis in patients receiving concurrent chemoradiotherapy and immunotherapy, providing a reference for revising lung dose constraints. Abstract Objective Combining immune checkpoint inhibitors (ICIs) with chemoradiotherapy is being actively ...
Ying Lu, Youjia Wang, Guang Han, Jianping Bi, Guoliang Pi, Xinbin Pan, Vivek Verma, Xiaofang Dai, Jiangqiong Huang, Ying Li   +9 more
wiley   +1 more source

<i>Bifidobacterium longum</i> B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan-Melatonin Metabolism. [PDF]

Foods
Liang L, Ke Q, Huang L, Hu S, Guo W, Luo W, Chen L, Wu Q.   +7 more
europepmc   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source