Results 111 to 120 of about 852,547 (280)

Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory mechanisms

Journal of Advanced Research
Background: Viral infectious diseases have long posed a challenge to humanity. In recent decades, transient receptor potential (TRP) channels have emerged as newly investigated cation channels.
Wen-Hui Qi, Na Tang, Zhi-Jing Zhao, Xiao-Qiang Li   +3 more
doaj   +1 more source

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Maihöfner Christian, Magerl Walter, Zhu, Jihong, Cascorbi Ingolf, Roman Rolke, Maihöfner, Christian, Binder Andreas, Treede, Rolf-Detlef, Faltraco, Frank, Flor, Herta, Rolf-Detlef Treede, Richter Helmut, Thomas R. Tölle, Nurcan Uçeyler, Huge, Volker, Mike Ufer, Christian Maihöfner, May, Denisa, Andrea Scherens, Uçeyler, Nurcan, Ralf Baron, May Denisa, Huge Volker, Cascorbi, Ingolf, Scherens, Andrea, Ufer, Mike, Gunnar Wasner, Binder, Andreas, Jihong Zhu, Herta Flor, Volker Huge, Helmut Richter, Tölle, Thomas R., Maier Christoph, Maier, Christoph, Thomas R Tölle, Tölle Thomas R., Zhu Jihong, Achim Berthele, Gierthmühlen Janne, Baron Ralf, Faltraco Frank, Magerl, Walter, Andreas Binder, Gierthmühlen, Janne, Christoph Maier, Richter, Helmut, Flor Herta, Wasner Gunnar, Denisa May, Scherens Andrea, Baron, Ralf, Üçeyler Nurcan, Haenisch Sierk, Rolke, Roman, Berthele Achim, Frank Faltraco, Ingolf Cascorbi, Berthele, Achim, Treede Rolf-Detlef, Ufer Mike, Haenisch, Sierk, Wasner, Gunnar, Janne Gierthmühlen, Sierk Haenisch, Rolke Roman, Walter Magerl   +66 more
core   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

TRP Channels in Cardiovascular Disease

, 2020
Transient receptor potential (TRP) channels are evolutionarily conserved ion channels that have been implicated in a wide range of physiological and pathophysiological responses.
Yu, Albert
core   +1 more source

TRP channels in vascular disorders

, 2013
In recent years, research on the roles of TRP channels in vascular function and disease has undergone a rapid expansion from tens of reports published in the early 2000s to several hundreds of papers published to date. Multiple TRP subtypes are expressed
Curtis, Timothy M, Zholos, Alexander V
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Structure and Dynamics of Porin Loops in Asymmetric Outer Membranes of E. coli

Chemistry – A European Journal, EarlyView.
What are loops of membrane proteins doing within the oligosaccharide coat of cells? This structurally unexplored space is studied by solid‐state NMR, with the outer membrane protein G (OmpG) embedded in asymmetric E. coli outer membrane (OM) vesicles as a paradigmatic example.
Morgane Adélaïde, Jayasubba Reddy Yarava, Florian Lindemann, Massilia Abbas, Nils Cremer, Lisa Gerland, Matthias Hiller, Barth van Rossum, Dirk Linke, Alexander B. Barnes, Edward P. Saliba, Özkan Yildiz, Werner Kühlbrandt, Hartmut Oschkinat   +13 more
wiley   +1 more source

Transient receptor potential channels as key regulators of cell death in atherosclerosis

Frontiers in Immunology
Transient receptor potential (TRP) channels are non-selective cation channels with diverse physiological functions, widely expressed across various cell types. These channels play crucial roles in maintaining homeostasis and contribute to the progression
Yibo Zhang, Weiguo Wang, Xuemin Li, Xuewen Li, Lei Zheng   +4 more
doaj   +1 more source

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

Chapter 20: TRP Channels in Cardiovascular Disease

, 2015
TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug ...
Luo, N, Singh, Kavisha, Rosenberg, P, Szallasi (ed), Arpad   +3 more
core   +1 more source