Results 111 to 120 of about 65,940 (289)

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

TRP Channels in Human Prostate

The Scientific World Journal, 2010
This review gives an overview of morphological and functional characteristics in the human prostate. It will focus on the current knowledge about transient receptor potential (TRP) channels expressed in the human prostate, and their putative role in ...
Carl Van Haute, Dirk De Ridder, Bernd Nilius   +2 more
doaj   +1 more source

TRP Channels in Skin Biology and Pathophysiology

Pharmaceuticals, 2016
Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to a host of chemical or physical stimuli. In the skin, TRP channels are expressed in many cell types, including
Michael J. Caterina, Zixuan Pang
doaj   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Probing the Influence of Sulfur–Aromatic Interactions on the Electronic Structure of Gas‐Phase Peptides

Chemistry – A European Journal, EarlyView.
Just as fingerprints reveal identity, spectroscopic fingerprints reveal molecular secrets. In this article, we show parts of the unique fingerprint of the sulfur–aromatic interaction. By measuring how this force alters the electronic structure of gas‐phase peptides, we provide a fundamental understanding of interactions that give insights into the ...
Laura Pille, Carlos Ortiz‐Mahecha, Bart Oostenrijk, Juliette Leroux, Marion Girod, Konstantin Hirsch, Luke MacAleese, Robert Horst Meißner, Debora Scuderi, Isaak Unger, Vicente Zamudio‐Bayer, Sadia Bari, Lucas Schwob   +12 more
wiley   +1 more source

TRP channels as potential targets for antischistosomals

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Ion channels are membrane protein complexes that underlie electrical excitability in cells, allowing ions to diffuse through cell membranes in a regulated fashion. They are essential for normal functioning of the neuromusculature and other tissues.
Swarna Bais, Robert M. Greenberg
doaj   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory mechanisms

Journal of Advanced Research
Background: Viral infectious diseases have long posed a challenge to humanity. In recent decades, transient receptor potential (TRP) channels have emerged as newly investigated cation channels.
Wen-Hui Qi, Na Tang, Zhi-Jing Zhao, Xiao-Qiang Li   +3 more
doaj   +1 more source