Results 131 to 140 of about 886,471 (280)
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Surface molds contribute to flavor development in dry‐cured fermented sausages through their effects on proteolysis, amino acid catabolism, and volatile compound formation. This study evaluated the influence of Aspergillus oryzae, Penicillium camemberti, Penicillium roqueforti and Penicillium nalgiovense on the evolution of free ...
José María Martín‐Miguélez +4 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Mucolipin TRP cation channel 1 (MCOLN1), also called TRPML1, drives the progression of various cancers and inhibits ferroptosis in a number of diseases. This study aimed to investigate whether MCOLN1 depletion regulates ferroptosis in gastric cancer and its molecular regulatory crosstalk with the AKT pathway.
Jing Wang +5 more
wiley +1 more source
Supraglottic Botulinum Toxin Injection Improves Symptoms of Laryngeal Sensory Dysfunction
The Laryngoscope, EarlyView.In this retrospective cohort of 80 patients with refractory laryngeal sensory symptoms, supraglottic botulinum toxin type A significantly improved Laryngeal Hypersensitivity Questionnaire, Reflux Symptom Index, and Cough Severity Index scores at a mean of 5.2 weeks, while Voice Handicap Index‐10 scores remained unchanged.
Daniel Novakovic +3 more
wiley +1 more source
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
core
Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao +3 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux +11 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Role of TRP channels in the cardiovascular system
, 2015 The transient receptor potential (TRP) superfamily consists of a large number of nonselective cation channels with variable degree of Ca(2+)-permeability.
Jonathan Stock +11 more
core +1 more source
Chapter 20: TRP Channels in Cardiovascular Disease
, 2015 TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug ...
Luo, N +3 more
core +1 more source
The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease
Pediatric Investigation, EarlyView.Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia +3 more
wiley +1 more source