Results 261 to 270 of about 65,940 (289)
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Annual Review of Cell and Developmental Biology, 2013
Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation.
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Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation.
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Advances in TRP channel drug discovery: from target validation to clinical studies
Nature Reviews Drug Discovery, 2021Ari-Pekka Koivisto +2 more
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TRP Channels and Thermosensation
2014Several TRP channels exhibit highly temperature-dependent gating properties, which leads to steep changes in depolarising current upon either cooling or heating. Based on this characteristic feature, these so-called "thermoTRPs" have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and ...
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Thermosensation and TRP Channels
Somatosensory neurons can sense external temperature by converting sensation of temperature information to neural activity via afferent input to the central nervous system. Various populations of somatosensory neurons have specialized gene expression, including expression of thermosensitive transient receptor potential (TRP) ion channels ...Makoto, Tominaga, Makiko, Kashio
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Sensory TRP Channels in Three Dimensions
Annual Review of Biochemistry, 2022Zanlin Yu, John V Lin King, David Julius
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Transient receptor potential channels as therapeutic targets
Nature Reviews Drug Discovery, 2011Magdalene M Moran +2 more
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Transient receptor potential channels: targeting pain at the source
Nature Reviews Drug Discovery, 2009Ardem Patapoutian, Clifford J Woolf
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