Results 141 to 150 of about 1,267,413 (183)

TRPA1 mediates formalin-induced pain

, 2007
The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary ...
McNamara, C.R., Hayward, N.J., Chong, J.A., Mandel-Brehm, J., Moran, M.M., Fanger, C.M., Deranian, K.L., Zhao, M., Bautista, D.M., Julius, D., Siemens, J.   +10 more
core   +1 more source

Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation. [PDF]

Int J Mol Sci, 2021
Kanda H, Yang Y, Duan S, Kogure Y, Wang S, Iwaoka E, Ishikawa M, Takeda S, Sonoda H, Mizuta K, Aoki S, Yamamoto S, Noguchi K, Dai Y.   +13 more
europepmc   +1 more source

Periorbital Nociception in a Progressive Multiple Sclerosis Mouse Model Is Dependent on TRPA1 Channel Activation. [PDF]

Pharmaceuticals (Basel), 2021
Dalenogare DP, Ritter C, Bellinaso FRA, Kudsi SQ, Pereira GC, Fialho MFP, Lückemeyer DD, Antoniazzi CTD, Landini L, Ferreira J, Bochi GV, Oliveira SM, De Logu F, Nassini R, Geppetti P, Trevisan G.   +15 more
europepmc   +1 more source

Molecular screening for potential selective antagonists of TRPA₁ ion channel

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article discusses the results of analysis a number of candidate molecules for TRPA1 ion channel selective antagonists using molecular modeling methods of high throughput screening. The study determined their mechanisms of action and specific activity
E. A. Beskhmelnitsyna, D. V. Kravchenko, M. V. Pokrovsky, M. V. Korokin, A. A. Peresypkina, E. I. Varavin, D. A. Kostina   +6 more
doaj  

Functional role of cytoplasmic domains in the gating of TRPA1 channel

, 2015
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in a subset of primary afferent neurones where it is activated by a variety of pungent and chemically reactive compounds such as allyl isothiocyanate or cinnamaldehyde.
Vašková, Jana
core  

The TRPA1 Channel Mediates Mechanical Allodynia and Thermal Hyperalgesia in a Rat Bone Cancer Pain Model. [PDF]

Front Pain Res (Lausanne), 2021
Liu Q, Feng L, Han X, Zhang W, Zhang H, Xu L.   +5 more
europepmc   +1 more source

Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis <i>via</i> inhibition of TRPA1 channel in retinal pigment epithelial cells. [PDF]

Int J Ophthalmol
Argun M, Nazıroğlu M.
europepmc   +1 more source

Identification of Phialomustin‑B (PHL-B) as a Novel Natural TRPA1 Channel Inhibitor. [PDF]

ACS Omega
Yadav P, Sharma A, Singh A, Sharma M, Singh AK, Ali A, Kshatri AS.   +6 more
europepmc   +1 more source

Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells. [PDF]

Cell Death Dis
Mancini V, Manganelli V, Garofalo T, Sorice M, Raffa S, Scullari D, Ranieri D, Belleudi F.   +7 more
europepmc   +1 more source

Recombinant Production, SpeciesSpecific Activity at the TRPA1 Channel, and Significance of the N-Terminal Residue of ProTx-I Toxin from Thrixopelma Pruriens Tarantula Venom. [PDF]

Acta Naturae
Shulepko MA, Zhang M, Zhivov EA, Kulbatskii DS, Paramonov AS, Che Y, Kuznetsov AV, Popov AV, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN.   +10 more
europepmc   +1 more source