Results 131 to 140 of about 1,267,413 (183)

Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel. [PDF]

Mar Drugs, 2022
Logashina YA, Lubova KI, Maleeva EE, Palikov VA, Palikova YA, Dyachenko IA, Andreev YA.   +6 more
europepmc   +1 more source

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Novel TRPA1 antagonist lead compound and its therapeutic potential in organophosphate poisoning

In Silico Research in Biomedicine
Organophosphate toxicity mediated by the TRPA1 ion channel presents a significant challenge in neurotoxicology. This study computationally explores a novel, potential inhibitory site within the TRPA1 channel pore, centered on the Serine 1039 residue ...
Shreya Satyanarayan Bhat, Spoorthi R Kulkarni, Vidya Niranjan, Rakesh Kumar Majhi, PhD   +3 more
doaj   +1 more source

Potential Common Mechanisms of Cytotoxicity Induced by Amide Herbicides via TRPA1 Channel Activation. [PDF]

Int J Environ Res Public Health, 2022
Wang X, Sun Y, Wang Q, Liu F, Yang W, Sui X, Yang J, Zhang M, Wang S, Xiao Z, Luo Y, Wang Y, Zhu T.   +12 more
europepmc   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Upregulation of DRG protein TMEM100 facilitates dry-skin-induced pruritus by enhancing TRPA1 channel function. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2022
Pan C, Jiao Y, Kong D, Deng H, Xu S, Tang D, Yin W, Gao P, Yu W, Fan Y, Wen D.   +10 more
europepmc   +1 more source

Garlic‐Derived Behavioural Deterrents: Diallyl Disulfide and TrpA1‐Mediated Suppression of Insect Reproduction

Modern Agriculture, Volume 4, Issue 2, December 2026.
Garlic‐derived diallyl disulfide acts as a behavioural deterrent that suppresses insect mating and oviposition through sensory pathways. The compound is detected through gustatory mechanisms involving the transient receptor potential A1 (TrpA1) channel and neural responses.
Sumit Singh, Shaoying Wu
wiley   +1 more source

Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure. [PDF]

Arch Toxicol, 2023
Müller-Dott K, Thiermann H, John H, Steinritz D.   +3 more
europepmc   +1 more source

Piezo1‐mediated unfolded protein response in goblet cells regulates intestinal mucus barrier homeostasis through the Ca2+–IRE1α–XBP1 pathway

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This study demonstrates that activation of Piezo1 channels in goblet cells by intestinal mechanical stimulation modulates ER calcium homeostasis via calcium ion (Ca2+) flux, which in turn regulates Mucin2 production and synthesis through the IRE1α‐XBP1. Intraperitoneal administration of Yoda1 alleviates mucus barrier impairment in DSS/WAS‐treated mice.
Jiandi Wu, Shaotong Wang, Zhe Wang, Jianhua Fang, Xueyan Li, Qingqing Zhang, Yan Dai, Wenjing Tian, Yize Ma, Gangping Li, Lei Zhang, Yudong Jiang, Xiaohua Hou, Jun Song   +13 more
wiley   +1 more source

TRPA1 ion channel is functionally expressed in CD4 positive T cells and reduces T cell mediated colitis via inhibition of TRPV1 [PDF]

, 2016
Inflammatory Bowel Diseases (IBD) are characterized by an abnormal inflammation in the small intestine and colon and are mainly mediated by CD4+ T cells.
Kim, Peter
core