TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice
The Journal of Physiology, EarlyView.Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
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The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel
Pharmacology Research & PerspectivesMethylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in ...
Ilari Mäki‐Opas +4 more
doaj +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
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Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
Role of reactive cysteines in the activation of the human TRPA1 ion channel [PDF]
, 2016 TRPA1 is a thermosensitive ion channel from the family of TRP (transient receptor potential) receptors. In primary sensory neurons, TRPA1 is an important transducer of painful stimuli, where it contributes to detection of noxious, irritant and ...
Synytsya, Viktor
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The role of transient receptor potential ankyrin 1 in pyroptosis during pulpitis development
BMC Oral HealthBackground Vital pulp therapy has been a widely adopted for managing pulp diseases, in which the control of pulpitis progression is critical. Although the transient receptor potential ankyrin 1 (TRPA1) channel mediates pain transduction and inflammatory ...
Sixue Huang +6 more
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Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms. [PDF]
Pharmaceutics, 2023 Fialho MFP +4 more
europepmc +1 more source
Urinary Lipid Production Profile of Patients With Food Allergy
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko +10 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Molecular dynamics simulations of ion channel TRPA1
, 2018 Title: Molecular dynamics simulations of ion channel TRPA1 Author: Mgr. Vlastimil Zíma Institute: Institute of Physics of Charles University Supervisor: RNDr. Ivan Barvík, PhD., Institute of Physics of Charles Uni- versity Abstract: The ion channel TRPA1
Zíma, Vlastimil
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