Results 101 to 110 of about 1,267,413 (183)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Effects of Pistacia lentiscus Leaf‐Twig and Resin (Mastic) Oils on Salivary Flow in Healthy Individuals

Oral Diseases, EarlyView.
ABSTRACT Objective Pistacia lentiscus L. tree is known for its aromatic mastic gum containing terpenes α‐pinene and β‐myrcene, and has been applied as a traditional remedy in oral care for centuries. Previously, intranasal exposure to mastic resin volatiles increased salivary flow in healthy and dry‐mouth individuals. This study assessed the biological
Wiktoria Potocka, Luca van Eijndthoven, Marja L. Laine, Floris J. Bikker, Zainab Assy   +4 more
wiley   +1 more source

TRPA1

, 2014
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation.
Zygmunt, Peter,, Högestätt, Edward,, Lund University.   +2 more
core   +2 more sources

The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production. [PDF]

Sci Adv, 2023
Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H.   +12 more
europepmc   +1 more source

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

A Potent and Site-Selective Agonist of TRPA1

, 2015
TRPA1 is a member of the transient receptor potential (TRP) cation channel family that is expressed primarily on sensory neurons. This chemosensor is activated through covalent modification of multiple cysteine residues with a wide range of reactive ...
Kazuhiro Mio (1276434), Shinya Otsuka (1453045), Junichiro Takaya (1453048), Tatsuki Kurokawa (1453042), Takuya Shiraishi (209576), Yasuo Mori (320114), Motonari Uesugi (509631)   +6 more
core   +1 more source

Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice. [PDF]

Cells, 2023
Dalenogare DP, Souza Monteiro de Araújo D, Landini L, Titiz M, De Siena G, De Logu F, Geppetti P, Nassini R, Trevisan G.   +8 more
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature

, 2017
trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance.
Ralf Stanewsky, Sanne Roessingh
core   +1 more source

CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain. [PDF]

Acta Pharm Sin B, 2023
Sun L, Zhang J, Niu C, Deering-Rice CE, Hughen RW, Lamb JG, Rose K, Chase KM, Almestica-Roberts M, Walter M, Schmidt EW, Light AR, Olivera BM, Reilly CA.   +13 more
europepmc   +1 more source