Results 81 to 90 of about 1,267,413 (183)

Ion Currents Mediated by TRPA1 Channels in Freshly Dissociated Rat Articular Chondrocytes: Biophysical Properties and Regulation by Inflammatory Processes

Pharmaceuticals
Background: Articular chondrocytes are specialized cells in synovial joint cartilage, responsible for maintaining and regenerating the extracellular matrix.
Arturo Ponce, Lidia Jimenez, Maria Luisa Roldan, Liora Shoshani   +3 more
doaj   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

TRPA1-Agonists: Novel bronchodilators?

, 2022
S.49-50TRPA1 is a cation channel of the transient receptor potential channel family that is predominantly expressed in sensory C-fibers and activated by a wide variety of environmental irritants and endogenous inflammatory mediators relevant for asthma ...
Spies, E., Kummer, W., Lee, J.-H., Haider, G., Wiegand, S., Hoymann, H.-G., Braun, A., Nassenstein, C.   +7 more
core   +1 more source

Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

Cellular and Molecular Gastroenterology and Hepatology, 2018
The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear.
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue   +11 more
doaj   +1 more source

In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

Journal of Pain Research, 2013
Eva Nyman,1,* Bo Franzén,1,* Andreas Nolting,1 Göran Klement,1 Gang Liu,1 Maria Nilsson,1 Annika Rosén,2 Charlotta Björk,3 Dirk Weigelt,4 Patrik Wollberg,1 Paul Karila,1 Patrick Raboisson11Neuroscience, Innovative ...
Nyman E, Franzén B, Nolting A, Klement G, Liu G, Nilsson M, Rosén A, Björk C, Weigelt D, Wollberg P, Karila P, Raboisson P   +11 more
doaj  

TRPA1 channel mediates methylglyoxal-induced mouse bladder dysfunction. [PDF]

Front Physiol, 2023
Oliveira AL, Medeiros ML, Gomes ET, Mello GC, Costa SKP, Mónica FZ, Antunes E.   +6 more
europepmc   +1 more source

Agonist‐induced sensitisation of the irritant receptor ion channel TRPA1 [PDF]

, 2016
The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) neurons and responds to a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard.
Meents, Jannis E., McNaughton, Peter A., Fischer, Michael J. M., McNaughton, Peter A.; id_orcid   +3 more
core   +1 more source

Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain

Molecules, 2016
The increasing demand for safe and effective treatments of chronic pain has promoted the investigation of novel analgesic drugs. Some herbals have been known to be able to relieve pain, while the chemical basis and target involved in this process ...
Shifeng Wang, Chenxi Zhai, Yanling Zhang, Yangyang Yu, Yuxin Zhang, Lianghui Ma, Shiyou Li, Yanjiang Qiao   +7 more
doaj   +1 more source