Results 61 to 70 of about 1,267,413 (183)

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites [PDF]

, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators has
Boa, Andrew N., Sadofsky, Laura R., McPhillie, MJ, McPhillie, Martin J., Boa, AN, Morice, Alyn H., Chandrabalan, A, Sadofsky, LR, Chandrabalan, Arundhasa, Morice, AH   +9 more
core   +1 more source

Calmodulin binding is required for calcium mediated TRPA1 desensitization

Nature Communications
TRPA1 is an essential calcium (Ca2+)-permeable channel involved in nociception and inflammation. It exhibits complex and mechanistically elusive Ca2+ regulation with initial potentiation then rapid desensitization.
Justin H. Sanders, Camila Garcia, Kehinde M. Taiwo, Gregory Quevedo, Glory A. Adekanye, Avnika Bali, Candice E. Paulsen   +6 more
doaj   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Purpose To summarize current Western and Eastern approaches to the evaluation and management of chronic cough, with particular emphasis on etiology‐directed therapy, cough hypersensitivity, behavioral interventions, neuromodulators, procedural treatments, and traditional remedies.
Thomas Zheng Jie Teng, Zhi Xuan Koh, Justin Yi Shen Lim, Kavimalar Ravi, Jin Wayne Kyler Ong, Christina Hui Lee Ng   +5 more
wiley   +1 more source

Nicotine activates the chemosensory cation channel TRPA1 [PDF]

, 2009
8 pages, 7 figures.-- Supporting information available at: http://www.nature.com/neuro/journal/vaop/ncurrent/suppinfo/nn.2379_S1.htmlArticle in press.Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the ...
Vennekens, Rudi, Nils Damann, Talavera, Karel, Vanoirbeek, Jeroen, Víctor M Meseguer, Voets, Thomas, Meseguer, Víctor M., Karel Talavera, Talavera Pérez, Karel, Karashima, Yuji, Benoit, Melissa, Félix Viana, Annelies Janssens, Gees, Maarten, Viana, Félix, Thomas Voets, Rudi Vennekens, Wouter Everaerts, Melissa Benoit, Benoit Nemery, Bernd Nilius, Yuji Karashima, Nilius, Bernd, Maarten Gees, Damann, Nils, Everaerts, Wouter, Jeroen A J Vanoirbeek, Nemery, Benoit, Vanoirbeek, Jeroen A. J., Janssens, Annelies   +29 more
core   +1 more source

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)

Integrative Zoology, EarlyView.
Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Involvement of TRPA1 Activation in Acute Pain Induced by Cadmium in Mice

Molecular Pain, 2013
Background Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear.
Saeko Miura, Kenji Takahashi, Toshiaki Imagawa, Kunitoshi Uchida, Shigeru Saito, Makoto Tominaga, Toshio Ohta   +6 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source