Results 71 to 80 of about 1,267,413 (183)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Binding and Activating of Analgesic Crotalphine with Human TRPA1

Membranes
TRPA1 (Transient Receptor Potential Ankyrin 1), a cation channel predominantly expressed in sensory neurons, plays a critical role in detecting noxious stimuli and mediating pain signal transmission.
Mingmin Kang, Yanming Zhang, Xiufang Ding, Jianfu Xu, Xiaoyun Pang   +4 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Warmth suppresses and desensitizes damage-sensing ion channel TRPA1

Molecular Pain, 2012
Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen, Lee Jongseok, Ro Jin Y, Chung Man-Kyo   +3 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

, 2011
TrpA1 is an ion channel involved in nociceptive and inflammatory pain. It is implicated in the detection of chemical irritants through covalent binding to a cysteine-rich intracellular region of the protein. While performing an HTS of the Pfizer chemical
Bodkin, Jennifer V., Peter Cox, Emma Fairman, Linda Kitching, Naoko Ishii, Rawson, David, Ryckmans, Thomas, Thomas Dupont, Kiyoyuki Omoto, Newman, Julie, Yoshinobu Hashizume, Aubdool, Aisah, Hashizume, Yoshinobu, Kitching, Linda, Thomas Ryckmans, Susan D. Brain, Kato, Teruhisa, Ishii, Naoko, Aisah A. Aubdool, Fairman, Emma, David Rawson, Omoto, Kiyoyuki, Teruhisa Kato, Brain, Susan D.; id_orcid, Dupont, Thomas, Jade Strover, Jennifer V. Bodkin, Julie Newman, Cox, Peter, Strover, Jade   +29 more
core   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception

Molecular Pain, 2012
Background The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines.
Weng Yingqi, Batista-Schepman Patricia A, Barabas Marie E, Harris Eli Q, Dinsmore Thomas B, Kossyreva Elena A, Foshage Audra M, Wang Michelle H, Schwab Matthew J, Wang Victoria M, Stucky Cheryl L, Story Gina M   +11 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel :

, 2013
While feverfew has been used for centuries to treat pain and headaches and is recommended for migraine treatment, the mechanism for its protective action remains unknown.
Patacchini, Riccardo, Materazzi, Serena, Nassini, Romina, Moncelli, Maria Rosa, Appendino, Giovanni, Fusi, Camilla, Geppetti, Pierangelo, Andersson, David A., Pollastro, Federica, Dussor, Gregory, Andersson, David A.; id_orcid, Gualdani, Roberta, Vastani, Nisha; id_orcid, Benemei, Silvia, Vastani, Nisha, Wei, Xiaomei, De Siena, Gaetano, Trevisan, Gabriela, Nassini, R., Fusi, C, Benemei, S, Geppetti, P, Gualdani, R, Trevisan, G, De Siena, G, Materazzi, S, Moncelli, Mr, Patacchini, R   +27 more
core   +1 more source