Results 91 to 100 of about 1,267,413 (183)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Colonic Hydrogen Sulfide–Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Cav3.2 and TRPA1 Channels in Mice

Journal of Pharmacological Sciences, 2012
Luminal hydrogen sulfide (H2S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca2+ channels.
Maho Tsubota-Matsunami, Yumi Noguchi, Yasumasa Okawa, Fumiko Sekiguchi, Atsufumi Kawabata   +4 more
doaj   +1 more source

Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel. [PDF]

Cell Discov, 2023
Wang X, Li Y, Wei H, Yang Z, Luo R, Gao Y, Zhang W, Liu X, Sun L.   +8 more
europepmc   +1 more source

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

Identifying Druggable Sites in the Pain-Sensing TRPA1 Ion Channel

, 2019
Transient receptor potential (TRP) channels, found in all eukaryotes, are a family of cation channels vital for critical physiological processes, such as mediating the sensation of unanticipated pain.
Skinner III, Kenneth Arthur
core   +2 more sources

Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels

Molecular Pain
Paclitaxel (PTX) is a drug commonly used in cancer chemotherapy despite its neurotoxicity. TRPA1 channels are essential mediators of sensory transduction and nociception. These cation channels are linked to PTX-induced neurotoxicity, which Li + prevents.
Julio C Sánchez, Aníbal Valencia-Vásquez, Juan C Olaya, Alexander Alemán, Jenifer Guerrero, Martín Torres, Luís F Martínez, Laura V Muñoz   +7 more
doaj   +1 more source

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1

Molecular Pain, 2008
Background A number of prostaglandins (PGs) sensitize dorsal root ganglion (DRG) neurons and contribute to inflammatory hyperalgesia by signaling through specific G protein-coupled receptors (GPCRs).
Cavanaugh Eric J, Montana Michael C, Young Timothy J, Heuermann Robert J, Dhaka Ajay, Cruz-Orengo Lillian, Kim Donghee, Story Gina M   +7 more
doaj   +1 more source

Noxious chemical discrimination by Tribolium castaneum TRPA1 channel in the HEK293 cell expression system. [PDF]

Curr Res Insect Sci, 2023
Shimomura K, Oikawa H, Yamamoto K, Terajima T, Yajima S, Tomizawa M.   +5 more
europepmc   +1 more source

Topical Alternatives for Preventing and/or Reducing Sensitivity Caused by In‐Office Tooth Bleaching: A Scoping Review

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective This scoping review aimed to (1) map, analyse, interpret and synthesize data from clinical trials on topical alternatives used to prevent and/or reduce sensitivity caused by in‐office tooth bleaching; and (2) characterize the available evidence on their use for managing sensitivity.
Erik Vinícius Martins Jácome, Jaderson Felipe Santos Dantas, Patricia Bittencourt Santos, Ana Clara Soares Paiva Torres   +3 more
wiley   +1 more source

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells. [PDF]

Cells, 2023
Moccia F, Montagna D.
europepmc   +1 more source