Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
The integrative function of TRPC channels
Frontiers in Bioscience, 2009 TRPC is a subfamily of Transient Receptor Potential channels that have the highest degree of homology to the Drosophila photoreceptors' TRP. TRPC open in response to stimulation of plasma membrane receptors that activate phospholipase C, triggering transmembrane Ca2+ influx.
Kirill, Kiselyov, Randen L, Patterson
openaire +2 more sources
Sociability is decreased following deletion of the _trpc4_ gene [PDF]
, 2011 Shyness and social anxiety are predominant features of some psychiatric disorders including autism, schizophrenia, anxiety and depression. Understanding the cellular and molecular determinants of sociability may reveal therapeutic approaches to treat ...
Andrew L. Varnell +4 more
core +2 more sources
Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster +3 more
wiley +1 more source
Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels
Cells, 2018 Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels.
Michael Mederos y Schnitzler +2 more
doaj +1 more source
Construction of a novel fungal gus expression plasmid, and its evaluation in Aspergillus nidulans : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University [PDF]
, 1996 A GUS expression plasmid, pFunGus, was constructed containing a multi-cloning site for the insertion of gene regulatory elements, to be used in fungal reporter gene studies.
McGowan, Tania Louise
core
Calcium-Dependent and Synapsin-Dependent Pathways for the Presynaptic Actions of BDNF [PDF]
, 2017 We used cultured hippocampal neurons to determine the signaling pathways mediating brain-derived neurotrophic factor (BDNF) regulation of spontaneous glutamate and GABA release. BDNF treatment elevated calcium concentration in presynaptic terminals; this
George J. Augustine +2 more
core +1 more source
Higher yields of cyclodepsipetides from Scopulariopsis brevicaulis by random mutagenesis [PDF]
, 2013 The ascomycete Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium, produces two cyclodepsipeptides, scopularides A and B [1]. Both peptides exhibit activity against several tumor cell lines.
Hihlal, ElKbir +5 more
core
Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?
Cells, 2014 In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich +2 more
doaj +1 more source
A key role of TRPC channels in the regulation of electromechanical activity of the developing heart [PDF]
, 2017 Aims It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart.
Raddatz, Eric +2 more
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