Results 131 to 140 of about 6,724 (162)

TRPC Channels and Mental Disorders

2017
Transient receptor potential canonical (TRPC) channels mediate the influx of different types of cations through the cell membrane and are involved in many functions of the organism. Evidences of involvement of TRPC channels in neuronal development suggest that this family of proteins might play a role in certain neurological disorders.
Karina, Griesi-Oliveira, Angela May, Suzuki, Alysson Renato, Muotri   +2 more
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TRPC Channels and Programmed Cell Death

2017
Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), bind to their high-affinity receptors to promote neuronal survival during brain development. One of the key downstream pathways is the phospholipase C (PLC) pathway, which not only plays a central role in calcium release from internal store but also in ...
Jian, Zhou, Yichang, Jia
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Inositol lipids and TRPC channel activation

Biochemical Society Symposia, 2007
The original hypothesis put forth by Bob Michell in his seminal 1975 review held that inositol lipid breakdown was involved in the activation of plasma membrane calcium channels or ‘gates’. Subsequently, it was demonstrated that while the interposition of inositol lipid breakdown upstream of calcium signalling was correct, it was predominantly the ...
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TRPC Channel Structure and Properties

2017
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+.
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The enigmatic TRPCs: multifunctional cation channels

Trends in Cell Biology, 2004
Abstract Canonical transient receptor potential (TRPC) channels are vertebrate homologs of the Drosophila photoreceptor channel. Considerable research has been carried out on the seven members of this family, particularly regarding their possible role in Ca 2+ entry.
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Physiological Functions and Regulation of TRPC Channels

2014
The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues.
Hwei Ling, Ong, Lorena B, de Souza, Kwong Tai, Cheng, Indu S, Ambudkar   +3 more
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Functional roles of TRPC channels in the developing brain

Pflügers Archiv - European Journal of Physiology, 2008
Transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental cues. Their expression begins
Yilin, Tai, Shengjie, Feng, Wanlu, Du, Yizheng, Wang   +3 more
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TRPC Channel Modulators and Their Potential Therapeutic Applications

Pharmaceutical Patent Analyst, 2015
The transient receptor potential canonical (TRPC) channels have gained interest as potential therapeutic targets for respiratory diseases, neurological disorders, cardiovascular disorders, pain, cancer and several other pathological conditions. The TRPC receptor family consists of seven isoforms (C1-C7) and has been divided into three subfamilies based
Neelima, Khairatkar-Joshi, Daisy M, Shah, Indranil, Mukhopadhyay, V S Prasadarao, Lingam, Abraham, Thomas   +4 more
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TRPC Channels in Cardiac Hypertrophy

2013
Impaired cardiomyocyte Ca2+ handling is considered as crucial factor programming cardiac hypertrophy and heart failure. It has, however, not been entirely resolved what type of Ca2+ signals is involved in mechanisms inducing hypertrophic remodelling.
Nadine Kirschmer, Kristina Lorenz, Petra Eder-Negrin   +2 more
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TRPC Channel Downstream Signaling Cascades

2017
The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
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