Results 161 to 170 of about 60,512,053 (199)
Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis <i>via</i> inhibition of TRPA1 channel in retinal pigment epithelial cells. [PDF]
Int J OphthalmolArgun M, Nazıroğlu M.
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The potential role of hypothalamic POMC<sup>TRPM2</sup> in interscapular BAT thermogenesis. [PDF]
Exp Mol MedYang JH +11 more
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Epigallocatechin gallate and thermal cycling‑stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress‑induced calcium ion dysregulation and oxidative stress. [PDF]
Mol Med RepHsu FT, Liu HH, Kung Y, Lin CJ, Chao CY.
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Calcium imbalance drives organelle network collapse and immune remodeling: novel pathogenic mechanisms in MASLD progression. [PDF]
Front ImmunolXu S, Jiang Z, Zhang Q, Guo J.
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TRPM2 is essential for phagocytosis in macrophages
TRPM2 is essential for phagocytosis in macrophagesopenaire +1 more source
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Roles of TRPM2 in Oxidative Stress
Cell Calcium, 2011Reactive oxygen species (ROS) play critical roles in cell death, diseases, and normal cellular processes. TRPM2 is a member of transient receptor potential (TRP) protein superfamily and forms a Ca(2+)-permeable nonselective cation channel activated by ROS, specifically by hydrogen peroxide (H(2)O(2)), and at least in part via second-messenger ...
Yasuo Mori +2 more
exaly +3 more sources
2007
TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i). It is widely expressed, e.g. in many neurons, blood cells and the endocrine pancreas. Channel gating is induced by ADP-ribose (ADPR) that binds to a Nudix box motif in the cytosolic C-terminus of the channel.
J, Eisfeld, A, Lückhoff
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TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i). It is widely expressed, e.g. in many neurons, blood cells and the endocrine pancreas. Channel gating is induced by ADP-ribose (ADPR) that binds to a Nudix box motif in the cytosolic C-terminus of the channel.
J, Eisfeld, A, Lückhoff
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Circulation Research, 2017 Rationale: TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca 2+ entry in response to ...
Jalees Rehman +2 more
exaly +2 more sources
2014
TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM) family of cation channels. The protein is widely expressed including in the brain, immune system, endocrine cells, and endothelia. It embodies both ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity.
Malika, Faouzi, Reinhold, Penner
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TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM) family of cation channels. The protein is widely expressed including in the brain, immune system, endocrine cells, and endothelia. It embodies both ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity.
Malika, Faouzi, Reinhold, Penner
openaire +2 more sources