Results 171 to 180 of about 60,512,053 (199)
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Neuropharmacology, 2006
TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of this channel have concentrated on human recombinant channels and rodent native preparations.
Hill, K +6 more
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TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of this channel have concentrated on human recombinant channels and rodent native preparations.
Hill, K +6 more
openaire +3 more sources
Lys1110 of TRPM2 is critical for channel activation
Biochemical Journal, 2013TRPM2 (transient receptor potential melastatin 2) is a non-selective Ca2+-permeable cation channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed in mammalian cells and plays an important role in the regulation of various cell functions.
Taek-Keun, Kim +11 more
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Biochemical and Biophysical Research Communications, 2019
Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD). Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive channel.
Tomohiro Numata +2 more
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Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD). Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive channel.
Tomohiro Numata +2 more
exaly +3 more sources
TRPM2 activation: Paradigm shifted?
Cell Calcium, 2018Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just ...
Ralf, Fliegert +2 more
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Architecture of the human TRPM2 channel
Science, 2018Structural Biology Adenosine diphosphate–ribose (ADPR) mediates calcium (Ca2+) release by activating the transient receptor potential melastatin 2 (TRPM2) channel. Three structures now elucidate the conformational regulation mechanism of TRPM2 gating. Wang et al.
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TRPM2 Channel Regulates Endothelial Barrier Function
2009Oxidative [Au1]stress, through the production of oxygen metabolites such as hydrogen peroxide[Au2] (H(2)O(2)), increases vascular endothelial permeability and plays a crucial role in several lung diseases. The transient receptor potential (melastatin) 2 (TRPM2) is an oxidant-sensitive, nonselective cation channel that is widely expressed in mammalian ...
Claudie M, Hecquet +2 more
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TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis
Cells, 2022Chun-Yin Lo, Xiaoqiang Yao, Xiao Li
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TRPM2: Bridging Calcium and ROS Signaling Pathways—Implications for Human Diseases
Frontiers in Physiology, 2023Yassine El Hiani, El Hiani Yassine
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