Results 111 to 120 of about 1,258,875 (180)

TRPM2-AS promotes ovarian cancer cell proliferation and inhibits cell apoptosis by upregulating the nearby gene TRPM2 via miR-6764-5p

Cell Division
Ovarian cancer (OC) becomes a fatal gynecologic malignant cancer in females worldwide. Target therapy is a promising therapeutical choice for patients with OC, and identifying biomarkers and exploring molecular mechanisms are necessary.
Wei Zhu, Shiqin Mao, Juan Jiang
doaj   +1 more source

Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy. [PDF]

Oxid Med Cell Longev, 2021
Hu X, Wu L, Liu X, Zhang Y, Xu M, Fang Q, Lu L, Niu J, Abd El-Aziz TM, Jiang LH, Li F, Li F, Yang W.   +12 more
europepmc   +1 more source

Evolution of Temperature Dependence of TRPM2 Channel Gating and Inactivation in Vertebrates

Journal of Molecular Biology
Abstract TRPM2 is a Ca 2+ permeable cation channel activated by cytosolic Ca 2+ and ADP ribose (ADPR). In contrast to invertebrate orthologs, vertebrate TRPM2 channels inactivate due to evolutionary alterations in amino acid sequence around the ...
Ádám Bartók, Ádám V. Tóth, László Csanády   +2 more
openaire   +1 more source

TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units

Cell Reports Medicine
Summary: Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death.
Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S. Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison, Yasuo Mori, Barbara Miller, Rajkumar Verma, Bruce Liang, Lixia Yue   +14 more
doaj   +1 more source

Deletion of Mitochondrial Translocator Protein (TSPO) Gene Decreases Oxidative Retinal Pigment Epithelial Cell Death via Modulation of TRPM2 Channel. [PDF]

Biology (Basel), 2021
Özkaya D, Shu X, Nazıroğlu M.
europepmc   +1 more source

Warm feelings for TRPM2

, 2016
Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures, both in the thermoregulatory center of the brain and in the somatosensory system.status ...
Voets, Thomas, Thomas Voets
core   +1 more source

Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation

Diabetes, Metabolic Syndrome and Obesity, 2019
Qi Feng, Chen Liu, Wei Gao, Xiao-ling Geng, Ning Dai Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, People’s Republic of ChinaCorrespondence: Ning DaiDepartment of ...
Feng Q, Liu C, Gao W, Geng X, Dai N
doaj  

Investigation Into the Pathogenesis of Type 2 Cardiorenal Syndrome via the ROS–TRPM2 Signaling Axis

Frontiers in Bioscience-Landmark
Background: Type 2 cardiorenal syndrome (CRS) is a complex disease characterized by the interplay between the heart and kidneys. The pathophysiology of type 2 CRS involves multiple molecular signaling pathways.
Yanxia Li, Fengrong Wang
doaj   +1 more source

The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site. [PDF]

J Gen Physiol, 2020
Lü W, Du J.
europepmc   +1 more source

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

Science Bulletin
Abstract Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a typical ancient ion channel, is activated by adenosine diphosphate ribose ...
Cheng Ma, Yanping Luo, Congyi Zhang, Cheng Cheng, Ning Hua, Xiaocao Liu, Jianan Wu, Luying Qin, Peilin Yu, Jianhong Luo, Fan Yang, Lin-Hua Jiang, Guojie Zhang, Wei Yang   +13 more
openaire   +2 more sources