Results 91 to 100 of about 1,258,875 (180)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

Frontiers in Immunology, 2020
TRPM2 is a non-selective, Ca2+-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR).
Ralf Fliegert, Winnie M. Riekehr, Andreas H. Guse   +2 more
doaj   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

TRPM2 ION CHANNEL REGULATES CANCER CELL SURVIVAL IN A CALCIUM-DEPENDENT MANNER

, 2018
Since the late 1990s, TRPM2 ion channels have been broadly studied in various cancer types. The positive effect of TRPM2 expression on cancer cell viability has been associated with reduced cancer patient survival.
Almasi, Shekoufeh
core  

Targeting TRPM2 in ROS-Coupled Diseases

Pharmaceuticals, 2016
Under pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease.
Shinichiro Yamamoto, Shunichi Shimizu
doaj   +1 more source

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source

A Multifaceted Approach Reveals Complex Genomic Mediation of White‐Nose Syndrome Adaptive Response in the Little Brown Bat (Myotis lucifugus)

Molecular Ecology, Volume 35, Issue 18, September 2026.
ABSTRACT Novel pathogens have become a major challenge faced by wildlife in the Anthropocene. White‐nose syndrome (WNS) has decimated bat populations across North America over the last two decades. Demographic and physiological evidence of adaptation in one heavily affected species, Myotis lucifugus, has prompted multiple attempts to delineate the ...
Samantha L. R. Capel, Devaughn L. Fraser, Kenneth A. Field, DeeAnn M. Reeder, Amy L. Russell, Peter H. Sudmant, Juan Manuel Vazquez, Maarten J. Vonhof, Thomas M. Lilley, Michael R. Buchalski   +9 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, Volume 16, Issue 8, Page 1477-1490, August 2026.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate. [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR).
László Csanády, Balázs Tóth, Iordanov, Iordan, Csanády, László, Iordan Iordanov, Tóth, Balázs   +5 more
core   +1 more source

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Active Immunization Using TRPM2 Peptide Vaccine Attenuates Atherosclerotic Progression in a Mouse Model of Atherosclerosis

Vaccines
Background/Objective: Atherosclerosis is one of the leading causes of cardiovascular diseases and mortality around the world. One exciting strategy for atherosclerosis treatment is immunotherapy, especially active immunization. Active immunization relies
Fan Ying, Yunting Zhang, Xiao Li, Zhaoyue Meng, Jingxuan Li, Chun-Yin Lo, Wentao Peng, Xiaoyu Tian, Xiaoqiang Yao   +8 more
doaj   +1 more source