Results 81 to 90 of about 1,258,875 (180)

Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability

MedComm
Epilepsy is one of the most common neurological disorders, characterized by the enhancement of neural excitability from a neurocentric perspective. Emerging evidence indicates that microglia play a pivotal role in the pathogenesis of epilepsy through ...
Yingwei Xu, Luyu Ye, Zhisheng Li, Yi Zhang, Ning Hua, Xiaojun Wang, Wangjialu Lu, Jing Xi, Liying Chen, Cenglin Xu, Jiajia Fang, Jianhong Luo, Linhua Jiang, Feng Han, Zhong Chen, Yi Wang, Wei Yang   +16 more
doaj   +1 more source

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Molecular Brain, 2012
Background Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca2+ dysregulation.
Belrose Jillian C, Xie Yu-Feng, Gierszewski Lynn J, MacDonald John F, Jackson Michael F   +4 more
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Regulation of Gating of TRPM2 Channels by Nucleotides, Ca2+, and Phospholipids [PDF]

Biophysical Journal, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) channels are Ca2+-permeable nonselective cation channels that are activated by oxidative stress and play important roles in immune cell activation, insulin secretion, and postischemic cell death. They are activated by ADP ribose (ADPR) binding to the carboxy-terminal cytosolic NUDT9-homology (NUDT9H ...
Csanády, László, Tóth, Balázs, Iordanov, Iordan, Töröcsik, Beáta   +3 more
openaire   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

The vital role of TRPM2 in breast cancer cell proliferation and its difference in expression between non-Hispanic white and non-Hispanic black females [PDF]

World Cancer Research Journal
Objective: To study the racial disparity of transient receptor potential melastatin-related channel subtype 2 (TRPM2) expression in non-Hispanic black (NHB) women and non-Hispanic white women (NHW) breast cancer tissues.
L. Huang, Y. Lu, M. Li
doaj   +1 more source

Transient Receptor Potential Melastatin 2 (TRPM2) Channel Plays a Role in Neonatal Hypoxic-ischemic Brain Injury [PDF]

, 2016
Recent advances in stroke research have identified non-glutamate mechanisms associated with ischemic neuronal death in adults. Among the molecules involved in non-glutamate mechanisms, transient receptor potential melastatin 2 (TRPM2), a calcium ...
Huang, Sammen
core  

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source