Results 101 to 110 of about 1,258,875 (180)

TRPM2 channels in mitochondrial dynamics and cancer [PDF]

Oncotarget, 2017
Sivaprasadarao, A, Abuarab, N, Li, F
openaire   +3 more sources

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons

, 2006
TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of
Benham, C.D., Randall, A.D., McNulty, S., Schaefer, M., Tigue, N., Hill, K., Kelsell, R.E.   +6 more
core   +2 more sources

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

, 2020
Parkinson's disease (PD) is one of most common neurodegenerative diseases. Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and inflammation mechanisms are linked to activated microglia in patients with PD.
Nazıroğlu, Mustafa, Yıldızhan, Kenan, NAZIROĞLU, Mustafa   +2 more
core   +1 more source

Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat β-Cell Line RIN-5F

Journal of Pharmacological Sciences, 2006
.: Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F.
Ishii Masakazu, Shimizu Shunichi, Hagiwara Tamio, Wajima Teruaki, Miyazaki Akira, Mori Yasuo, Kiuchi Yuji   +6 more
doaj   +1 more source

Extinction of contextual fear memory is facilitated in TRPM2 knockout mice

Molecular Brain
Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm2 −/− ) mice ...
Seung Yeon Ko, Do Gyeong Kim, Huiju Lee, Sung Jun Jung, Hyeon Son   +4 more
doaj   +1 more source

TRPM2 Channel Inhibition Attenuates Amyloid β42-Induced Apoptosis and Oxidative Stress in the Hippocampus of Mice. [PDF]

Cell Mol Neurobiol, 2023
Çınar R, Nazıroğlu M.
europepmc   +1 more source

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

, 2011
The generation of reactive oxygen species (ROS) is inherent to immune responses. ROS are crucially involved in host defense against pathogens by promoting bacterial killing, but also as signaling agents coordinating the production of ...
Ellen Shapland, Jennifer Mogan, Alastair D. Morrison, Justin W. Heizer, Heather Knowles, Yuan Li, Karl Andreasen, Gary Kucera, Jessica Humann, Anne-Laure Perraud, Carol Anne Ogden, Kathryn Chapman, Laurel L. Lenz   +12 more
core   +1 more source

Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line. [PDF]

Graefes Arch Clin Exp Ophthalmol, 2023
Ertuğrul A, Özkaya D, Nazıroğlu M.
europepmc   +1 more source

Transient receptor potential melastatin-2 (TRPM2) channel in breast cancer cells unique localization and cellular role [PDF]

, 2013
Transient receptor potential melastatin-2 (TRPM2) channel is a non-selective cation channel that is widely expressed throughout the body. It has been shown to be associated with cancer progression, neurodegenerative disorders, inflammatory responses, and
Liu, Mengwei
core   +2 more sources

8‐Br‐cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia–reperfusion injury

, 2019
The transient receptor potential melastatin-2 (TRPM2) channel belongs to the transient receptor potential channel superfamily and is a cation channel permeable to Na+ and Ca (2+).
Elif Polat, Polat, Elif, Eraslan, Ersen, Tanyeli, Ayhan, Ayhan Tanyeli, Ersen Eraslan   +5 more
core   +1 more source