Results 61 to 70 of about 1,258,875 (180)
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Nudt9H Interactions in the Tetrameric TRPM2 Ion Channel [PDF]
Biophysical Journal, 2014 TRPM2 is a Ca2+-permeable cation channel that belongs to the M subfamily of Transient Receptor Potential (TRP) channel proteins. TRPM2 is a homotetramer, each monomer contains a cytosolic N-terminal TRPM-homology region, six transmembrane helices with an architecture typical to that of voltage-gated cation channels, and a cytosolic coiled-coil region ...
Iordanov, Iordan, Csanady, Laszlo
openaire +1 more source
Frontiers in Immunology, 2020 During infection, phagocytic cells pursue homeostasis in the host via multiple mechanisms that control microbial invasion. Neutrophils respond to infection by exerting a variety of cellular processes, including chemotaxis, activation, phagocytosis ...
Frank H. Robledo-Avila +5 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 The present study is aimed to elucidate the possible involvement of the thermosensitive TRPM2 ion channel in changing of the temperature sensitivity of the hypothalamus after different cold exposures—long-term adaptation to cold and short-term cooling ...
Anna A. Evtushenko +2 more
doaj +1 more source
Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao +3 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
eLife, 2019 Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov +3 more
doaj +1 more source
Microglial TRPM2 Channel Activation and Its Relationship to Neurodegenerative Diseases [PDF]
, 2017 Microglial cell plays a key role in neuroinflammation induced by diverse danger associated molecular patterns (DAMP) molecules, such as Zn2+, Aβ42 and TNF-α, and strongly implicated in neurodegenerative diseases.
Syed Mortadza, Sharifah Alawieyah
core +4 more sources
TRPM2: a pivotal player in tumor progression and a promising therapeutic target
Cancer Cell InternationalTRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous ...
Zhigang Chen +4 more
doaj +1 more source
Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)
Integrative Zoology, EarlyView.Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley +1 more source