Results 51 to 60 of about 1,258,875 (180)

Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Ventilator has been widely used for life support, but ventilator-induced lung injury (VILI) is still a major problem. Oxidative stress has been considered as a key contributor for VILI, but the specific mechanism remains unclear.
Xiaona An, Xiaotong Sun, Xiaomei Yang, Dejie Liu, Yonghao Hou, Hongli Chen, Jianbo Wu   +6 more
doaj   +1 more source

Neuroimmune Regulation by TRPM2 Channels

Cells
Mutual interaction between the nervous and immune systems underpins many pathophysiological processes. Transient Receptor Potential Melastatin 2 (TRPM2) channels are abundantly expressed in both systems, acting as a critical interface of neuroimmune interaction.
Zhang, Xuming, Malhotra, Mitali
openaire   +2 more sources

Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation

Journal of Inflammation, 2023
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related as well as sterile inflammation.
Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen, Yi Liu, Yi Zhao, Martin Herrmann   +8 more
doaj   +1 more source

The TRPM2-PARP-1 Axis Involvement in Bisphenol A and Nonylphenol-Induced Ferroptosis in Trigeminal Ganglion Cells. [PDF]

J Appl Toxicol
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Yazğan B, Tatar M, Yazğan Y, Tüfekci KK.   +3 more
europepmc   +2 more sources

Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis

Boletín Médico del Hospital Infantil de México, 2016
Background: Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel
Adriana Sumoza-Toledo, Mario Iván Espinoza-Gabriel, Dvorak Montiel-Condado   +2 more
doaj   +1 more source

Direct and Indirect Effectors of the TRPM2 Cation Channel [PDF]

Biophysical Journal, 2010
TRPM2 is a Ca2+ permeable cation channel which plays a role in physiological and pathophysiological processes linked to oxidative stress. TRPM2 channels are co-activated by intracellular Ca2+ and ADP ribose (ADPR). In addition, in intact cells, a large number of compounds appear to modulate TRPM2 activity.
Tóth, Balázs, Csanády, László
openaire   +1 more source

Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway

Neurobiology of Disease, 2023
Epilepsy is one of the most common neurological disorders. Neuroinflammation involving the activation of microglia and astrocytes constitutes an important and common mechanism in epileptogenesis.
Chen Chen, Tao Zhu, Lifen Gong, Zhe Hu, Hao Wei, Jianchen Fan, Donghui Lin, Xiaojun Wang, Junyu Xu, Xinyan Dong, Yifan Wang, Ningxiao Xia, Linghui Zeng, Peifang Jiang, Yicheng Xie   +14 more
doaj   +1 more source

Signalling mechanisms mediating Zn 2+ -induced TRPM2 channel activation and cell death in microglial cells [PDF]

, 2017
Excessive Zn 2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H 2 O 2 /Zn 2+ -induced Ca 2+ signalling and cell death in microglial cells.
Stacey, Martin, Jiang, Lin Hua, Sim, Joan A., Sim, JA, Lin-Hua Jiang, Martin Stacey, Stacey, M, Syed Mortadza, S, Sharifah Syed Mortadza, Mortadza, Sharifah Syed, Jiang, LH, Joan A. Sim   +11 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Effects of Extracellular Ca2+ on TRPM2 Channel Gating [PDF]

Biophysical Journal, 2011
TRPM2 is a non-selective cation channel, which is activated by intracellular ADPR and Ca2+. ADPR binds to the C-terminal NUDT9-H domain of the channel, while the binding sites for Ca2+ remain unidentified. In a previous study (J. Gen. Physiol., 133(2):189-203), we demonstrated that extracellular Ca2+ has no effect on steady-state channel gating ...
Tóth, Balázs, Csanády, László
openaire   +1 more source