Results 31 to 40 of about 1,258,875 (180)
The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice [PDF]
, 2023 IntroductionDuring thermogenesis, adipose tissue (AT) becomes more active and enhances oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” and, together with the brown AT (BAT) activation, is considered as a ...
Memushaj, Adela +37 more
core +1 more source
The TRPM2 ion channel is required for sensitivity to warmth [PDF]
Nature, 2016 Thermally activated ion channels are known to detect the entire thermal range from extreme heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and TRPV4) and non-painful coolness (TRPM8) through to painful cold (TRPA1). Genetic deletion of each of these ion channels, however, has only modest effects on thermal behaviour in ...
Tan, Chun Hsiang, McNaughton, Peter A.
openaire +3 more sources
A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway
Journal of Diabetes Investigation, 2022 Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves blood glucose levels through multiple mechanisms of action including the enhancement of glucose‐stimulated insulin secretion (GSIS), however, the details of this mechanism have ...
Shunsuke Funazaki +7 more
doaj +1 more source
Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells. [PDF]
PLoS ONE, 2012 Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and cationic non-selective channel that is expressed in mammalian vascular endothelium. Here we investigated the functional role of TRPM2 channels in hydrogen peroxide
Lei Sun +5 more
doaj +1 more source
In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2 [PDF]
Science Signaling, 2009 Cationic channels of the TRP melastatin family are involved in pigmentation and oxidative stress responses.
Sandip, Patel, Roberto, Docampo
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TRPM2: a multifunctional ion channel for calcium signalling [PDF]
The Journal of Physiology, 2011 The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death. Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for
Adriana, Sumoza-Toledo, Reinhold, Penner
openaire +2 more sources
Function and modulation of TRPM2 channels [PDF]
, 2013 Melastatin-related transient receptor potential 2 (TRPM2) channel is a Ca2+-permeable cation channel that is gated by ADP-ribose (ADPR) and also activated by reactive oxygen species (ROS) such as H2O2. TRPM2 channel are shown to be critically involved in
Zou, Jie
core +4 more sources
A critical role of TRPM2 channel in Aβ₄₂‐induced microglial activation and generation of tumor necrosis factor‐α [PDF]
, 2017 Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor potential melastatin‐related 2 (TRPM2) channel in Aβ‐induced neuroinflammation, but how Aβ induces ...
Alawieyah Syed Mortadza, S. +11 more
core +1 more source
A novel disease connection for TRPM2 channels [PDF]
Channels, 2014 Alzheimer's Disease (AD) is a progressive neurodegenerative condition responsible for dementia in older adults and for which no effective treatment is available.
openaire +2 more sources
TRPM2 Is Not Required for T-Cell Activation and Differentiation
Frontiers in Immunology, 2022 Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracellular
Niels C. Lory +17 more
doaj +1 more source