Results 41 to 50 of about 1,258,875 (180)
The ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis [PDF]
Radiation and Environmental Biophysics, 2018 Radiodermatitis is a painful side effect for cancer patients undergoing radiotherapy. Irradiation of the skin causes inflammation and breakdown of the epidermis and can lead to significant morbidity and mortality in severe cases, as seen in exposure from accidents or weapons such as "dirty bombs" and ultimately leads to tissue fibrosis.
Anne-Laure Perraud +5 more
openaire +2 more sources
Technology in Cancer Research & Treatment, 2021 Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of death due to cancer, indicating that finding new therapeutic targets or approaches for ESCC treatment is imperative. Transient Receptor Potential cation channel subfamily M, member 2
Xingbang Wang MD +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2012 When cardiac tissue is exposed to hypoxia, myocytes are damaged, while fibroblasts are activated. However, it is unknown what changes are induced by hypoxia in cardiac fibroblasts.
Kenji Takahashi +2 more
doaj +1 more source
Life, 2021 The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions.
Andras Szollosi
doaj +1 more source
Inactivation of TRPM2 Channels by Extracellular Divalent Copper
PLoS ONE, 2014 Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we showed that human melastatin transient receptor potential 2 (hTRPM2) channel is sensitive to inhibition by extracellular Cu2+.
Yu, W +5 more
openaire +5 more sources
State-dependent Inhibition of TRPM2 Channel by Acidic pH [PDF]
Journal of Biological Chemistry, 2010 Transient receptor potential melastatin 2 (TRPM2) channel fulfills an important role in oxidative stress signaling in immune and other cells, to which local extracellular acidosis is known to occur under physiological or pathological conditions and impose significant effects on their functions.
Yang, Wei +7 more
openaire +2 more sources
eLife, 2016 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov +3 more
doaj +1 more source
Assessment of temperature sensitivity of the TRPM2 channel [PDF]
, 2021 TRPM2 belongs to the TRP family, and is expressed in neurons of the central nervous system, bone marrow, phagocytes, β-cells, and cardiomyocytes. It forms Ca2+-permeable nonselective cation channels that open under oxidative stress by simultaneous ...
Csanády, László, Bartok, Adam
core +1 more source
TRPM2 channels mediate acetaminophen-induced liver damage [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Acetaminophen overdose is the most common cause of acute liver failure and the leading cause of chronic liver damage requiring liver transplantation in developed countries. There are limited options for early treatment.
Kheradpezhouh, Ehsan +4 more
openaire +5 more sources
TRPM2 Channels: A Potential Therapeutic Target in Melanoma?
International Journal of Molecular Sciences, 2023 The transient receptor potential, the melastatin (TRPM) subfamily, which consists of eight known members, appears to have significant importance in melanoma progression, treatment, and prognosis. As several members were originally cloned from cancerous tissue, initial studies aimed towards identifying TRPM involvement in cancer progression and ...
Hattie M. Foster +3 more
openaire +2 more sources