The TRPM2 channel in temperature detection and thermoregulation. [PDF]
Temperature (Austin), 2017 Kamm GB, Siemens J.
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Mechanism of TRPM2 Channel Gating Revealed by Cryo-EM [PDF]
FEBS Journal, 2019 Hao Wu, Shiyu Xia, Tian-Min Fu
exaly +2 more sources
The TRPM2 channel: A thermo-sensitive metabolic sensor. [PDF]
Channels (Austin), 2017 Living organisms continually experience changes in ambient temperature. To detect such temperature changes for adaptive behavioral responses, we evolved the ability to sense temperature. Thermosensitive transient receptor potential (TRP) channels, so-called thermo-TRPs, are involved in many physiologic functions in diverse organisms and constitute ...
Kashio M, Tominaga M.
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Reply to: Heat detection by the TRPM2 ion channel [PDF]
Nature, 2020 sponsorship: We thank all members of the Laboratories of Ion Channel Research and Experimental Gynecology and Obstetrics for comments and discussion. This work was supported by grants from KU Leuven Research Council (C1-TRPLe to T.V), the Research Foundation-Flanders (FWO G.084515N to J.V.
Mulier, Marie +3 more
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Frontiers in Aging Neuroscience, 2022 Transient receptor potential melastatin 2 (TRPM2), a non-selective cation channel, is involved in many physiological and pathological processes, including temperature sensing, synaptic plasticity regulation, and neurodegenerative diseases.
Yuhuan Luo +4 more
doaj +1 more source
TRPM2 channel: A novel target for alleviating ischaemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxic-ischaemic brain damage. [PDF]
J Cell Mol Med, 2020 The transient receptor potential melastatin-related 2 (TRPM2) channel, a reactive oxygen species (ROS)-sensitive cation channel, has been well recognized for being an important and common mechanism that confers the susceptibility to ROS-induced cell ...
Mai C +6 more
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Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel [PDF]
, 2020 Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves +6 more
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Selective Inhibition of TRPM2 Channel by Two Novel Synthesized ADPR Analogues [PDF]
Chemical Biology and Drug Design, 2018 KeWei Wang, Xiao Luo, Liangren Zhang
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TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis
Cells, 2022 Atherosclerosis is a chronic inflammatory arterial disease characterized by build-up of atheromatous plaque, which narrows the lumen of arteries. Hypercholesterolemia and excessive oxidative stress in arterial walls are among the main causative factors ...
Yunting Zhang +8 more
doaj +1 more source
A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol [PDF]
Metabolic Brain Disease, 2022 The overload cytosolic free Ca2+ (cCa2+) influx-mediated excessive generation of oxidative stress in the pathophysiological conditions induces neuronal and cellular injury via the activation of cation channels. TRPM2 and TRPV4 channels are activated by oxidative stress, and their specific antagonists have not been discovered yet.
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