Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation [PDF]
eLife, 2018 Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang +4 more
doaj +4 more sources
Metabolite of SIR2 reaction modulates TRPM2 Ion channel [PDF]
Journal of Biological Chemistry, 2006 The transient receptor potential melastatin-related channel 2 (TRPM2) is a nonselective cation channel, whose prolonged activation by oxidative and nitrative agents leads to cell death.
Scharenberg, Andrew M. +7 more
core +4 more sources
Identification of Ligands for Ion Channels: TRPM2
ChemBioChemTransient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, nonselective cation channel with a widespread distribution throughout the body.
Liu, Miaomiao +3 more
core +4 more sources
Glutathione Decreases Parkinsonism‐Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells [PDF]
Pharmacology Research & PerspectivesParkinson's disease (PD) is the most prevalent neurodegenerative disease. Previously, it was believed that aberrant iron metabolism, leading to ferroptosis due to glutathione (GSH) depletion, excessive Ca2+ influx, mitochondrial (mROS), and cytosolic ...
Elif Güzel +2 more
doaj +2 more sources
Right Place, Right Function: The Contribution of Subcellular Localization to the Physiological Impact of TRPM2 Channels [PDF]
LifeThe channel TRPM2 forms cation-selective channels and is activated by redox-dynamics, including oxidative stress. Initially described at the plasma membrane, TRPM2 has been found to also localized to intracellular compartments, i.e., nucleus ...
Alice Hasselsweiller +3 more
doaj +2 more sources
A bibliometric analysis using VOSviewer of publications on the TRPM2 channel
Eastern Journal Of MedicineThe transient receptor potential melastatin 2 (TRPM2) is a Ca2+ permeable cation channel that is a cellular redox sensor. It has been determined that the TRPM2 channel plays an important role in various neurological disorders such as Alzheimer's and ...
Yıldızhan, Kenan +3 more
core +3 more sources
Pathophysiological significance of the TRPM2 ion channel as a potential target in cancer, neurological disorders, and ischemia/reperfusion injury [PDF]
Pharmacological ResearchThe transient receptor potential melastatin 2 (TRPM2) ion channel is a redox-sensitive, non-specific cation channel that plays a vital role in the regulation of Ca2+ homeostasis and cellular functions in response to oxidative stress.
Sara Sultana +3 more
doaj +2 more sources
Bilirubin Gates the TRPM2 Channel as a Direct Agonist to Exacerbate Ischemic Brain Damage [PDF]
Neuron, 2023 Lu-Yang Wang, Hao-Song Shi
exaly +2 more sources
Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases [PDF]
Neural Plasticity, 2016 Synaptic plasticity refers to the ability of neurons to strengthen or weaken synaptic efficacy in response to activity and is the basis for learning and memory.
Jing Wang +2 more
doaj +4 more sources
TRPM2 Channel-Mediated Signalling Mechanisms for Neuronal Cell Death [PDF]
, 2017 Transient receptor potential melastatin-related 2 (TRPM2) channel is gated by ADP-ribose (ADPR) and potently activated by reactive oxygen species (ROS) through stimulating ADPR-generating mechanisms. Recent studies provide evidence to show a crucial role
Li, Xin
core +5 more sources