Results 71 to 80 of about 1,258,875 (180)
TRPM2-AS promotes the malignancy of osteosarcoma cells by targeting miR-15b-5p/PPM1D axis
, 2022 Osteosarcoma (OS) is a malignant tumor with a low survival rate and a high incidence rate worldwide. Although research has reported the involvement of long non-coding RNAs (lncRNAs) in the pathogenesis of OS cells, the role of TRPM2-AS, miR-15b-5p, and ...
Yingchun Cai (3809575) +4 more
core +1 more source
Scientific Reports, 2022 Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including mitochondrial function, bioenergetics, and oxidative stress.
Lei Bao +6 more
doaj +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2. [PDF]
PLoS ONE, 2012 For mammalian TRPM8, the amino acid residues asparagine-799 and aspartate-802 are essential for the stimulation of the channel by the synthetic agonist icilin.
Mathis Winking +5 more
doaj +1 more source
Research, 2023 Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong +16 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
Journal of Pharmacological Sciences, 2006 .: A brief exposure to hydrogen peroxide (H2O2) induces severe deterioration of primary cultured neurons in vitro. We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR).
Kaneko Shuji +10 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Synergistic impairment of the blood-brain barrier (BBB) induced by methamphetamine (METH) and HIV-Tat protein increases the risk of HIV-associated neurocognitive disorders (HAND) in HIV-positive METH abusers.
Jian Huang +19 more
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice
The Journal of Physiology, EarlyView.Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley +1 more source